Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.
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Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresIntracellular Calcium Dysregulation: Implications for Alzheimer's DiseaseMechanisms of amyloid formation revealed by solution NMRUsing neuroimaging to evaluate and guide pharmacological and psychotherapeutic treatments for mood disorders in children.Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.Endoplasmic reticulum stress and inflammation in the central nervous systemCalcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases.Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology.Endocytosed 2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils.Picomolar sensitivity to inositol trisphosphate in Xenopus oocytes.Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer diseaseAlzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms.Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.Calcium regulation of neural rhythms, memory and Alzheimer's disease.Modulating Ca2+ release by the IP3R/Ca2+ channel as a potential therapeutic treatment for neurological diseases.Network-wide dysregulation of calcium homeostasis in Alzheimer's disease.The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Amyloid pore-channel hypothesis: effect of ethanol on aggregation state using frog oocytes for an Alzheimer's disease study.Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease.Vitamin D, reactive oxygen species and calcium signalling in ageing and disease.Emerging pathways driving early synaptic pathology in Alzheimer's disease.IP3 receptor mutations and brain diseases in human and rodents.Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides.Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy.Effects of Low Amyloid-β (Aβ) Concentration on Aβ1-42 Oligomers Binding and GluN2B Membrane Expression.Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development.An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging.Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells.Dysregulation of Intracellular Calcium Signaling in Alzheimer's DiseaseA mathematical model for the effects of amyloid beta on intracellular calcium
P2860
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P2860
Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
@en
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
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type
label
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
@en
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
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prefLabel
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
@en
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
@nl
P2860
P1476
Cytotoxicity of intracellular ...... ion of inositol trisphosphate.
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P2093
Angelo Demuro
Ian Parker
P2860
P304
P356
10.1523/JNEUROSCI.4367-12.2013
P407
P577
2013-02-01T00:00:00Z