Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
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Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compoundsNew 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligandsNew opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptidesLigands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities.
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P2860
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2005
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH
@nl
Conversion of the potent delta ...... )-benzimidazole alkylation(1).
@en
type
label
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH
@nl
Conversion of the potent delta ...... )-benzimidazole alkylation(1).
@en
prefLabel
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH
@nl
Conversion of the potent delta ...... )-benzimidazole alkylation(1).
@en
P2093
P2860
P356
P1476
Conversion of the potent delta ...... )-benzimidazole alkylation(1).
@en
P2093
Elisa Giannini
Gianfranco Balboni
Lawrence H Lazarus
Lucia Negri
Sharon D Bryant
Yunden Jinsmaa
P2860
P304
P356
10.1021/JM058259L
P407
P577
2005-12-01T00:00:00Z