Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.
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A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury.A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury.A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injuryA data-driven approach for evaluating multi-modal therapy in traumatic brain injury.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticusA small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.A Rehabilomics framework for personalized and translational rehabilitation research and care for individuals with disabilities: Perspectives and considerations for spinal cord injury.Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.Quantitative evaluation of 3D mouse behaviors and motor function in the open-field after spinal cord injury using markerless motion tracking.Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice.The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol DrinkingAdult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury.Dynamic nature of the p75 neurotrophin receptor in response to injury and diseaseFrom demyelination to remyelination: the road toward therapies for spinal cord injury.The p75 neurotrophin receptor: at the crossroad of neural repair and death.ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels.VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling.Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury.AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury.ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints: a novel pathogenic mechanism in chronic arthritis.Electrical and neurotrophin enhancement of neurite outgrowth within a 3D collagen scaffold.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Unique sensory and motor behavior in Thy1-GFP-M mice before and after spinal cord injury.A preclinical model of hyperalgesia following spinal stenosis/compression.Kinetics of chemically mediated neurodegeneration/neuroregeneration of mouse olfactory epithelium: monitoring by hyperlayer sedimentation field flow fractionation.Genetic and pharmacological intervention of the p75NTR pathway alters morphological and behavioural recovery following traumatic brain injury in mice.Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury.Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.
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P2860
Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Oral administration of a small ...... very after spinal cord injury.
@en
Oral administration of a small ...... very after spinal cord injury.
@nl
type
label
Oral administration of a small ...... very after spinal cord injury.
@en
Oral administration of a small ...... very after spinal cord injury.
@nl
prefLabel
Oral administration of a small ...... very after spinal cord injury.
@en
Oral administration of a small ...... very after spinal cord injury.
@nl
P2093
P2860
P1476
Oral administration of a small ...... very after spinal cord injury.
@en
P2093
Chhavy Tep
Frank M Longo
Jae Cheon Ryu
Michele Basso
Pyung On Ko
Sami Getahun
Stephen M Massa
Sung Ok Yoon
Tae Hee Lim
Virginia M Goettl
P2860
P304
P356
10.1523/JNEUROSCI.0399-12.2013
P407
P577
2013-01-01T00:00:00Z