Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
about
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phaseThe tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phaseThe APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobinThe beta-catenin binding protein ICAT modulates androgen receptor activityLoss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc geneA targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumorsSequence variation in the Fanconi anemia gene FAAMolecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VIICombined immunohistochemistry of beta-catenin, cytokeratin 7, and cytokeratin 20 is useful in discriminating primary lung adenocarcinomas from metastatic colorectal cancer.Animal models of colorectal cancerMolecular Basis for the Recognition of Adenomatous Polyposis Coli by the Discs Large 1 ProteinAxin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilonQuantification of crypt and stem cell evolution in the normal and neoplastic human colonRelationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min miceGenetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoLoss of adenomatous polyposis coli gene function disrupts thymic developmentThe molecular basis of genetic dominanceRegulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor proteinA knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.Variable phenotype of familial adenomatous polyposis in pedigrees with 3' mutation in the APC gene.Frequent promoter hypermethylation of the APC and RASSF1A tumour suppressors in parathyroid tumours.Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis.Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects.Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families.Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations?A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli's disease.Familial adenomatous polyposis.A novel deletion at codon 441 of the APC gene associated with ophthalmic lesions (CHRPE) in a South African family.Genetics and clinicopathological findings in thyroid carcinomas associated with familial adenomatous polyposisFamilial adenomatous polyposis in a 5 year old child: a clinical, pathological, and molecular genetic studyPresymptomatic diagnosis in Portuguese FAP families using intragenic RFLPs and (CA)n flanking markers by fluorescence based semiautomated DNA analysis.Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology.APC gene mutations in Chinese familial adenomatous polyposis patients.Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR.Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancerGenetic testing and counseling for hereditary forms of colorectal cancer.Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancerWhole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.
P2860
Q22011189-0D9AB030-28ED-4B70-93F8-7CD458535DFFQ24310213-1DADAED9-A96F-4223-B8ED-2F4E09CB9580Q24317231-5FB932A0-07F2-47FF-9244-97C792C69470Q24337124-C58C24EC-D347-4F78-B280-50293EFF229BQ24562061-881F355B-1680-4827-866B-CC865E9F1B68Q24564011-D68BD92A-9219-4407-8F4C-E390ADA3A865Q24657452-225DEFAA-2654-4E4E-9A98-A10D701018E9Q24676351-6BAA4678-9CB6-410A-82C1-87CB7E955763Q25257315-43325634-F260-4376-B75F-74C57EDD4019Q27009170-9BA57BFB-ABBC-4114-87B5-B013D607A032Q27671865-D87FFECE-7C75-4BBB-9C8C-E6489E3A1720Q28211035-DD3701DD-C5FA-4612-BE4B-224E81018966Q28246034-7C5CFBB5-A021-4D92-8535-59BC8BAAE829Q28374489-EC32A629-4EAF-4ADA-9221-8181202291FEQ28472494-62915541-C441-410D-BBF3-ED5FEB7F1B80Q28508640-31291C86-C659-4DD9-8228-E539D311D71CQ28972447-C002D0D8-3CA1-4818-B42A-DAFE614A404CQ29614383-C856069D-9081-49E8-AF32-D1A50B15B653Q30424003-1C32E801-92C0-4F7A-BB41-82E855959684Q30444901-43552AAF-0C19-4512-9F87-8DEDD07BF2C8Q30979173-500F0A17-52F6-420D-AE49-5CC18CB4E189Q30991987-C67C7172-B161-4718-8157-FBED23E7DD37Q33281301-B40FEDDE-B24A-4178-A280-86D530B26993Q33330514-5567EF16-572F-4229-BC18-B4CC23E2EA14Q33468643-5C63B94C-9DA6-445F-BD68-AB075B8408E7Q33554605-39B8A93B-72A3-4C5A-8C8C-D2607F7E9161Q33595283-687E46C3-4319-4E50-9A61-A8946F0E8D44Q33624843-23A9C99F-FE63-4C60-8899-D69D3068FB0EQ33677324-037CC818-3B15-48DF-98D6-6E7188DD3F7CQ33679392-7026DDCD-1C84-4B22-8F34-B32521BDFC91Q33683226-791544DD-D1C3-42C1-835D-B01C97124007Q33683385-7F4E1582-EFB6-4CD0-8B75-952AB1B96F9EQ33742739-FE077040-E839-4B62-B6F1-E2BA4A81AF1CQ33756298-AF53D613-8FB6-466C-945C-884601A74E1CQ33786781-FDBD1925-55F0-47B1-AFF5-64C93B013026Q33788100-5C6370BC-4BAF-4D48-934B-DA172726AB9EQ33814001-7482A496-E697-4193-BA36-EED3199476D9Q34001641-397EF986-F421-4982-95F5-362FD11D1F0BQ34015467-E2D8BBD7-B9B9-4A39-9FAB-58AD40C1D03FQ34093651-BF18C390-B235-4BF3-95DC-1B6A34E65FFA
P2860
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@en
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@nl
type
label
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@en
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@nl
prefLabel
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@en
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@nl
P2093
P2860
P356
P1476
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
@en
P2093
Nishisho I
Petersen G
Utsunomiya J
P2860
P304
P356
10.1073/PNAS.89.10.4452
P407
P577
1992-05-01T00:00:00Z