Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.
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The search for novel analgesics: targets and mechanismsBasic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor HeteromerizationPositive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatmentNovel GPCR paradigms at the μ-opioid receptorPutative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer modelInhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction.G Protein-Coupled Receptor Heteromers.Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord.Pharmacological Profiles of Oligomerized μ-Opioid Receptors.G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.G-protein-coupled receptor type A heteromers as an emerging therapeutic target.Current and Future Issues in the Development of Spinal Agents for the Management of Pain.Contribution of heteromerization to G protein-coupled receptor function.Organization and functions of mGlu and GABAB receptor complexes.Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures.Breaking barriers to novel analgesic drug development.Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.G protein-coupled receptors: a double attack on pain.Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice.Influence of social interaction on nociceptive-induced changes in locomotor activity in a mouse model of acute inflammatory pain: Use of novel thermal assays.Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay.
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P2860
Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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name
Ligands that interact with put ...... roduce potent antinociception.
@en
Ligands that interact with put ...... roduce potent antinociception.
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type
label
Ligands that interact with put ...... roduce potent antinociception.
@en
Ligands that interact with put ...... roduce potent antinociception.
@nl
prefLabel
Ligands that interact with put ...... roduce potent antinociception.
@en
Ligands that interact with put ...... roduce potent antinociception.
@nl
P2093
P2860
P356
P1476
Ligands that interact with put ...... produce potent antinociception
@en
P2093
Eyup Akgün
Mary M Lunzer
Muhammad I Javed
Philip S Portoghese
P2860
P304
11595-11599
P356
10.1073/PNAS.1305461110
P407
P577
2013-06-24T00:00:00Z