The multiple lives of NMD factors: balancing roles in gene and genome regulation
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Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complexProteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsActivation of Src and transformation by an RPTPĪ± splice mutant found in human tumoursFunctional characterization of mutations in the myosin Vb gene associated with microvillus inclusion diseaseUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2Endogenous mechanisms for the origins of spliceosomal intronsRNA around the clock - regulation at the RNA level in biological timingInsights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complexStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex5-lipoxygenase mRNA and protein isoformsAttenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppressionThe sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decayIn Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydisThe life history of retrocopies illuminates the evolution of new mammalian genesListerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociationMutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the production of diploid pollen grainsA novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cellsCongenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Genome-wide mapping of alternative splicing in Arabidopsis thalianaEffects of PTCs on nonsense-mediated mRNA decay are dependent on PTC locationNormalized long read RNA sequencing in chicken reveals transcriptome complexity similar to human.Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruptionThe UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinomaNonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.A yeast model of FUS/TLS-dependent cytotoxicity.The role of mRNA splicing in prostate cancer.TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells.The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity.When a ribosome encounters a premature termination codon.Preventing dangerous nonsense: selection for robustness to transcriptional error in human genes.Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors.The pioneer round of translation: features and functionsLoss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1Deficiency in nucleotide excision repair family gene activity, especially ERCC3, is associated with non-pigmented hair fiber growth.
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The multiple lives of NMD factors: balancing roles in gene and genome regulation
description
article cientĆfic
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article scientifique
@fr
articolo scientifico
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artigo cientĆfico
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bilimsel makale
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scientific article published on September 2008
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vedeckĆ½ ÄlĆ”nok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vÄdeckĆ½ ÄlĆ”nek
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name
The multiple lives of NMD factors: balancing roles in gene and genome regulation
@en
The multiple lives of NMD factors: balancing roles in gene and genome regulation.
@nl
type
label
The multiple lives of NMD factors: balancing roles in gene and genome regulation
@en
The multiple lives of NMD factors: balancing roles in gene and genome regulation.
@nl
prefLabel
The multiple lives of NMD factors: balancing roles in gene and genome regulation
@en
The multiple lives of NMD factors: balancing roles in gene and genome regulation.
@nl
P2860
P356
P1476
The multiple lives of NMD factors: balancing roles in gene and genome regulation
@en
P2093
Olaf Isken
P2860
P2888
P304
P356
10.1038/NRG2402
P577
2008-09-01T00:00:00Z
P5875
P6179
1042761161