Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines.
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MicroRNA-regulated viral vectors for gene therapyReplication in cells of hematopoietic origin is necessary for Dengue virus disseminationThe role of RNAi and microRNAs in animal virus replication and antiviral immunityVaccines: the Fourth CenturyMicroRNA-Detargeted Mengovirus for Oncolytic VirotherapyAltered viral replication and cell responses by inserting microRNA recognition element into PB1 in pandemic influenza A virus (H1N1) 2009.Experimental vaccines against potentially pandemic and highly pathogenic avian influenza virusesUse of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cellsMicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interferenceAttenuation of vesicular stomatitis virus encephalitis through microRNA targeting.Drosha as an interferon-independent antiviral factor.MicroRNAs and the regulation of vector tropismExploring the fitness landscape of an RNA virus by using a universal barcode microarraySilencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regionsThe Mammalian response to virus infection is independent of small RNA silencing.Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.In vitro and in vivo characterization of microRNA-targeted alphavirus replicon and helper RNAs.Rationalizing the development of live attenuated virus vaccinesExploiting microRNA regulation for genetic engineering.High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries.MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activityA computational tool for the design of live attenuated virus vaccine based on microRNA-mediated gene silencingInsertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype.MicroRNA-mediated suppression of oncolytic adenovirus replication in human liverMicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expressionMammalian MicroRNAs: Post-Transcriptional Gene Regulation in RNA Virus Infection and Therapeutic Applications.Coxsackievirus B3 engineered to contain microRNA targets for muscle-specific microRNAs displays attenuated cardiotropic virulence in mice.Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences.MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacyParallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repressionViruses and microRNAs: RISCy interactions with serious consequences.Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses.Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSVGeneration of a safe and effective live viral vaccine by virus self-attenuation using species-specific artificial microRNA.Host-virus interaction: the antiviral defense function of small interfering RNAs can be enhanced by host microRNA-7 in vitro.In vivo delivery of cytoplasmic RNA virus-derived miRNAs.MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype.A Polymerase mechanism-based strategy for viral attenuation and vaccine development.Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response.The extent of sequence complementarity correlates with the potency of cellular miRNA-mediated restriction of HIV-1.
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Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
@en
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
@nl
type
label
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
@en
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
@nl
prefLabel
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
@en
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
@nl
P2860
P50
P1433
P1476
Harnessing endogenous miRNAs t ...... ing attenuated virus vaccines.
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P2093
Dwight Barnes
Raul Andino
P2860
P304
P356
10.1016/J.CHOM.2008.08.003
P577
2008-09-01T00:00:00Z