MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression - Wikidata - awgldk - TriplyDB

MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

http://www.wikidata.org/entity/Q34621747

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MicroRNA-regulated viral vectors for gene therapy Current prospects and challenges for epilepsy gene therapy Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan.Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors MicroRNA-restricted transgene expression in the retina E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus Retinal gene delivery by rAAV and DNA electroporation.A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice.Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.Systemic gene delivery to the central nervous system using Adeno-associated virus.Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10 The potential of adeno-associated viral vectors for gene delivery to muscle tissue.MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation Gene transfer to the CNS using recombinant adeno-associated virus Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders Exploiting microRNA regulation for genetic engineering.Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology.MicroRNAs as potential therapeutics for treating spinal cord injury.Methods for gene transfer to the central nervous system.Application of mutated miR-206 target sites enables skeletal muscle-specific silencing of transgene expression of cardiotropic AAV9 vectors.Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System.In vivo delivery of miRNAs for cancer therapy: challenges and strategies.Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.Recombinant AAV as a platform for translating the therapeutic potential of RNA interference.Genetic therapy for the nervous system.Epigenetic treatment of neurological disease.Molecular neurosurgery: vectors and vector delivery strategies.The advent of AAV9 expands applications for brain and spinal cord gene delivery.A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.Small RNA drugs for prion disease: a new frontier.Systemic AAV9-IFNβ gene delivery treats highly invasive glioblastoma.Plasmodium meets AAV-the (un)likely marriage of parasitology and virology, and how to make the match.Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity.CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector.Gene vector 'magic bullet': targeted expression in the central nervous system after peripheral delivery using the synapsin promoter.

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P2860

MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

http://www.wikidata.org/entity/Q34621747

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

MicroRNA-regulated, systemical ...... estricted transgene expression

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MicroRNA-regulated, systemical ...... estricted transgene expression

@en

MicroRNA-regulated, systemical ...... estricted transgene expression

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type

label

MicroRNA-regulated, systemical ...... estricted transgene expression

@ast

MicroRNA-regulated, systemical ...... estricted transgene expression

@en

MicroRNA-regulated, systemical ...... estricted transgene expression

@nl

prefLabel

MicroRNA-regulated, systemical ...... estricted transgene expression

@ast

MicroRNA-regulated, systemical ...... estricted transgene expression

@en

MicroRNA-regulated, systemical ...... estricted transgene expression

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P1433

Molecular Therapy

P1476

MicroRNA-regulated, systemical ...... estricted transgene expression

@en

P2093

Chengjian Li

http://www.w3.org/2001/XMLSchema#string

Christian Mueller

http://www.w3.org/2001/XMLSchema#string

Craig C Mello

http://www.w3.org/2001/XMLSchema#string

Guangping Gao

http://www.w3.org/2001/XMLSchema#string

Hiroki Kato

http://www.w3.org/2001/XMLSchema#string

Hongwei Zhang

http://www.w3.org/2001/XMLSchema#string

Jun Xie

http://www.w3.org/2001/XMLSchema#string

Qin Su

http://www.w3.org/2001/XMLSchema#string

Qing Xie

http://www.w3.org/2001/XMLSchema#string

Ran He

http://www.w3.org/2001/XMLSchema#string

P2860

MicroRNAs: target recognition and regulatory functions

RNA interference is mediated by 21- and 22-nucleotide RNAs

Silencing of microRNAs in vivo with 'antagomirs'

Identification of tissue-specific microRNAs from mouse

A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication

A proteinase inhibitor II of Solanum americanum is expressed in phloem.

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).

Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons.

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.

P304

526-535

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scholarly article

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10.1038/MT.2010.279

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3

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19

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Stefan L Ameres

Phillip D. Zamore

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2010-12-21T00:00:00Z

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49703025

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21179009

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3048189

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