Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
about
BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.Metformin inhibits RANKL and sensitizes cancer stem cells to denosumab.Metformin targets histone acetylation in cancer-prone epithelial cells.Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model.
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Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 02 March 2016
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
@en
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome.
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type
label
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
@en
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome.
@nl
prefLabel
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
@en
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome.
@nl
P2860
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Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
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Núria Folguera-Blasco
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P304
11959-11971
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10.18632/ONCOTARGET.7867
P407
P577
2016-03-01T00:00:00Z