Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. - Wikidata - awgldk - TriplyDB

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.

http://www.wikidata.org/entity/Q37031862

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Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery The hitchhiker's guide to the voltage-gated sodium channel galaxy Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels Theoretical and simulation studies on voltage-gated sodium channels Na+ channel function, regulation, structure, trafficking and sequestration Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.Action of clathrodin and analogues on voltage-gated sodium channels.MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats.The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.Activation of peripheral KCNQ channels relieves gout pain.Novel sodium channel antagonists in the treatment of neuropathic pain.Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells.The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening On the role of water density fluctuations in the inhibition of a proton channel The role of the dorsal root ganglion in the development of neuropathic pain.Size does matter! Label-free detection of small molecule-protein interaction.Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010.Voltage gated sodium channels as drug discovery targets Functional Studies of Sodium Channels: From Target to Compound Identification.Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves.Breaking barriers to novel analgesic drug development.Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1.Protein-Protein Interactions as New Targets for Ion Channel Drug Discovery.Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.

http://www.wikidata.org/entity/Q37031862

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on July 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Voltage sensor interaction sit ...... voltage-gated sodium channels.

@en

Voltage sensor interaction sit ...... voltage-gated sodium channels.

@nl

type

label

Voltage sensor interaction sit ...... voltage-gated sodium channels.

@en

Voltage sensor interaction sit ...... voltage-gated sodium channels.

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Voltage sensor interaction sit ...... voltage-gated sodium channels.

@en

Voltage sensor interaction sit ...... voltage-gated sodium channels.

@nl

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PNAS.1220844110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Voltage sensor interaction sit ...... voltage-gated sodium channels.

@en

P2093

Brett M Antonio

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Brian E Marron

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Christopher W West

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David Printzenhoff

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Douglas S Krafte

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Karen M Padilla

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Ken McCormack

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Marcel de Groot

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Mark L Chapman

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Michael J Krambis

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P2860

A quantitative description of membrane current and its application to conduction and excitation in nerve

Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor

The crystal structure of a voltage-gated sodium channel

An SCN9A channelopathy causes congenital inability to experience pain

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury

Targeting voltage sensors in sodium channels with spider toxins.

Ion channel voltage sensors: structure, function, and pathophysiology.

Voltage-gated ion channels and gating modifier toxins.

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E2724-32

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scholarly article

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10.1073/PNAS.1220844110

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29

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110

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2013-07-01T00:00:00Z

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244482667

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23818614

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3718154

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