The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
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The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brainValue of monitoring Nrf2 activity for the detection of chemical and oxidative stressMechanisms of drug-induced liver injurySuppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cellsNovel -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial ExtensionTumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategiesPotential role of olive oil phenolic compounds in the prevention of neurodegenerative diseasesThe novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cellsNrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosisEffects of dietary supplementation with ferulic Acid or vitamin e individually or in combination on meat quality and antioxidant capacity of finishing pigsChemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoidsNrf2 signaling and cell survivalThe role of Nrf1 and Nrf2 in the regulation of copper-responsive transcriptionInflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- MiceNrf2:INrf2 (Keap1) signaling in oxidative stressMolecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane.PR-104 plus sorafenib in patients with advanced hepatocellular carcinoma.Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor.Redox regulation in cancer: a double-edged sword with therapeutic potential.Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domainsThe cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expressionGalangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes.Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundanceThe protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2.Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis.Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells.Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study.The Core Promoter and Redox-sensitive Cis-elements as Key Targets for Inactivation of the Lysyl Oxidase Gene by CadmiumInnate immune evasion by filovirusesThe role of Nrf2 in pathology of pleomorphic adenoma in parotid glandThe effect of Nrf2 pathway activation on human pancreatic islet cells.Treatment With Dimethyl Fumarate Attenuates Calcineurin Inhibitor-induced Nephrotoxicity.Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs.Microtubules as a critical target for arsenic toxicity in lung cells in vitro and in vivoHeme oxygenase-1 attenuates cadmium-induced mitochondrial-caspase 3- dependent apoptosis in human hepatoma cell lineNrf2 links epidermal barrier function with antioxidant defenseCurcumin attenuates chronic ethanol-induced liver injury by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 pathway in mice.Changes in hepatic gene expression in response to hepatoprotective levels of zinc.
P2860
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P2860
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@en
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@nl
type
label
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@en
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@nl
prefLabel
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@en
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@nl
P2093
P1433
P1476
The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
@en
P2093
B Kevin Park
Christopher E Goldring
Ian M Copple
Neil R Kitteringham
P356
10.1016/J.TOX.2007.10.029
P407
P577
2007-11-12T00:00:00Z