Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP
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Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic WindowGlutamatergic targets for new alcohol medicationsRole of cues and contexts on drug-seeking behaviourDifferential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P ratsEthanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Exercise as a potential treatment for drug abuse: evidence from preclinical studiesAlterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats.Metabotropic glutamate receptors: from the workbench to the bedside.Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanolAdenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation.Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbensMetabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intakeEffects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependenceCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.Overexpression of 5-HT(1B) mRNA in nucleus accumbens shell projection neurons differentially affects microarchitecture of initiation and maintenance of ethanol consumptionAssessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinkingAlcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors.Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala.Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol.Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependenceIntra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol.Therapeutic potential of metabotropic glutamate receptor modulators.Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathwaysmGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behaviorIncreased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL/6J mice.Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice.mGlu receptors and drug addiction.CaMKIIα-GluA1 Activity Underlies Vulnerability to Adolescent Binge Alcohol Drinking.Group 1 mGlu-family proteins promote neuroadaptation to ethanol and withdrawal-associated hippocampal damage.The α7nACh-NMDA receptor complex is involved in cue-induced reinstatement of nicotine seekingEnhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatementOral Conditioned Cues Can Enhance or Inhibit Ethanol (EtOH)-Seeking and EtOH-Relapse Drinking by Alcohol-Preferring (P) Rats.Glutamate and reinstatement.Development of pharmacotherapies for drug addiction: a Rosetta stone approach.Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala.Focus on: Neuroscience and treatment: the potential of neuroscience to inform treatment.Neuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence.
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Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 04 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP
@en
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP.
@nl
type
label
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP
@en
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP.
@nl
prefLabel
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP
@en
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP.
@nl
P2093
P2860
P1433
P1476
Cue-induced reinstatement of a ...... by the mGluR5 antagonist MPEP
@en
P2093
Jason P Schroeder
Jennie R Stevenson
Joyce Besheer
Marina Spanos
Michael Salling
P2860
P304
P356
10.1016/J.NEUROPHARM.2008.06.057
P577
2008-07-04T00:00:00Z