SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells.
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WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersK-Cl cotransporters, cell volume homeostasis, and neurological diseaseMolecular mechanism of pancreatic and salivary gland fluid and HCO3 secretionSTK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysisCurrent view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Full transcriptome analysis of early dorsoventral patterning in zebrafishCrystal structure of domain-swapped STE20 OSR1 kinase domainIdentification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lensesA SPAK isoform switch modulates renal salt transport and blood pressureStructural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.Behavioral analysis of Ste20 kinase SPAK knockout mice.Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells.STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporterComplement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.Coordinated control of volume regulatory Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells.Molecular components of signal amplification in olfactory sensory cilia.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.Phosphorylation state of the Na+-K+-Cl- cotransporter (NKCC1) in the gills of Atlantic killifish (Fundulus heteroclitus) during acclimation to water of varying salinity.In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosteroneShort forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.Antagonists of the Vasopressin V1 Receptor and of the β(1)-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes - but the Mechanisms Differ.SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse modelsThe WNKs: atypical protein kinases with pleiotropic actions.C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signalingCation-chloride cotransporters in neuronal development, plasticity and diseaseSPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.Genetic association study between STK39 and CCDC62/HIP1R and Parkinson's diseaseImpaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndromeSPAK-mediated NCC regulation in response to low-K+ dietWith-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volumeSPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Regulatory activation is accompanied by movement in the C terminus of the Na-K-Cl cotransporter (NKCC1).Critical role of the SPAK protein kinase CCT domain in controlling blood pressureMolecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
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SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@en
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@nl
type
label
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@en
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@nl
prefLabel
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@en
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@nl
P356
P1433
P1476
SPAK and OSR1: STE20 kinases i ...... me control in mammalian cells.
@en
P2093
Eric Delpire
Kenneth B E Gagnon
P304
P356
10.1042/BJ20071324
P407
P577
2008-01-01T00:00:00Z