SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. - Wikidata - awgldk - TriplyDB

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

http://www.wikidata.org/entity/Q35623025

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2 Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2 Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation Ion transporters in brain tumors Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues.SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity Potassium and Its Discontents: New Insight, New Treatments Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling Hypertension: the missing WNKs.Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain Direct control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosterone Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis.With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis.Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.Novel missense mutations of WNK1 in patients with hypokalemic salt-losing tubulopathies.WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis.Distal convoluted tubule.OSR1-sensitive small intestinal Na+ transport.WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4.

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SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

http://www.wikidata.org/entity/Q35623025

description

2012 nî lūn-bûn

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name

SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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SPAK/OSR1 regulate NKCC1 and W ...... oop trans-autophosphorylation.

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Alberto C Vitari

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Fatema H Rafiqi

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Jacob O Thastrup

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P2860

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

Structural insights into the recognition of substrates and activators by the OSR1 kinase

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II

Characterization of the kinase activity of a WNK4 protein complex

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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325-337

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