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DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsSystems biology analysis reveals role of MDM2 in diabetic nephropathySerum anti-MDM2 and anti-c-Myc autoantibodies as biomarkers in the early detection of lung cancer.MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4.Wiring miRNAs to pathways: a topological approach to integrate miRNA and mRNA expression profilesTargeting autophagy in breast cancer.Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes.Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice.TP53 and MDM2 polymorphisms and the risk of endometrial cancer in postmenopausal womenA quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study.Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implicationsUSP11 regulates p53 stability by deubiquitinating p53.Expression of p53 target genes in the early phase of long-term potentiation in the rat hippocampal CA1 areaLactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts.Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases.MicroRNA-410 suppresses migration and invasion by targeting MDM2 in gastric cancer.Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice.Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation.RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel.Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.The Expression and Function of NUMB in Endometrial Cancer and the Interaction with HDM2 and P53Potential Therapeutic Targets in Uterine Sarcomas.Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action.Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapAThe T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitorPrognostic value of decreased expression of RBM4 in human gastric cancerIdentification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapyRelationship Between Murine Double Minute 2 (MDM2) T309G Polymorphism and Endometrial Cancer Risk: A Meta-Analysis.Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes.Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway.Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapyNovel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma.Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.Does not hUTP14a promoter form a regulation feedback loop with P53?Effects and mechanisms of blocking the hedgehog signaling pathway in human gastric cancer cells.Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumorsMDM2 promoter del1518 polymorphism and cancer risk: evidence from 22,931 subjects.JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.Tumor suppression: putting p53 in context.Regulation of p53 in NIH3T3 mouse fibroblasts following hyperosmotic stress.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 06 June 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The MDM2-p53 pathway revisited
@en
The MDM2-p53 pathway revisited.
@nl
type
label
The MDM2-p53 pathway revisited
@en
The MDM2-p53 pathway revisited.
@nl
prefLabel
The MDM2-p53 pathway revisited
@en
The MDM2-p53 pathway revisited.
@nl
P2860
P50
P356
P1476
The MDM2-p53 pathway revisited
@en
P2093
Minghai Wang
Ruiwen Zhang
P2860
P304
P356
10.7555/JBR.27.20130030
P577
2013-06-06T00:00:00Z