Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins.
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Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemiaEvidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and manOxidized low density lipoprotein: atherogenic and proinflammatory characteristics during macrophage foam cell formation. An inhibitory role for nutritional antioxidants and serum paraoxonase.Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesionsCholesteryl ester accumulation in mouse peritoneal macrophages induced by beta-migrating very low density lipoproteins from patients with atypical dysbetalipoproteinemiaAggregation and fusion of low-density lipoproteins in vivo and in vitro.Dominant negative mutations of the scavenger receptor. Native receptor inactivation by expression of truncated variants.Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4Probucol inhibits oxidative modification of low density lipoprotein.Pre-beta-very low density lipoproteins as precursors of beta-very low density lipoproteins. A model for the pathogenesis of familial dysbetalipoproteinemia (type III hyperlipoproteinemia)Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia.High receptor binding affinity of lipoproteins in atypical dysbetalipoproteinemia (type III hyperlipoproteinemia)Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjectsSaturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.Role of platelets in cholesteryl ester formation by U-937 cellsModification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.Lipoprotein-heparin-fibronectin-denatured collagen complexes enhance cholesteryl ester accumulation in macrophagesUptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoproteinModification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.Lipoprotein lipase secretion by human monocytes and rabbit alveolar macrophages in cultureSpecificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins.Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemiaLow density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes. A possible mechanism of foam cell formation.Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.Low density lipoprotein receptor activity in human monocyte-derived macrophages and its relation to atheromatous lesionsAspirin protects low density lipoprotein from oxidative modification.Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E.Apolipoprotein E synthesis in human kidney, adrenal gland, and liver.Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages.Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.The action of peroxyl radicals, powerful deleterious reagents, explains why neither cholesterol nor saturated fatty acids cause atherogenesis and age-related diseases.Role of macrophages in regression of atherosclerosis.Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene.The role of free radicals and antioxidants: how do we know that they are working?Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles.Human (THP-1) macrophages oxidize LDL by a thiol-dependent mechanism.
P2860
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P2860
Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1979
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Altered metabolism (in vivo an ...... e residues of the apoproteins.
@en
Altered metabolism
@nl
type
label
Altered metabolism (in vivo an ...... e residues of the apoproteins.
@en
Altered metabolism
@nl
prefLabel
Altered metabolism (in vivo an ...... e residues of the apoproteins.
@en
Altered metabolism
@nl
P2093
P2860
P356
P1476
Altered metabolism (in vivo an ...... e residues of the apoproteins.
@en
P2093
Innerarity TL
Weisgraber KB
P2860
P304
P356
10.1172/JCI109518
P407
P577
1979-09-01T00:00:00Z