MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
about
Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer.Framework to function: mechanosensitive regulators of gene transcriptionTAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma.MRTF potentiates TEAD-YAP transcriptional activity causing metastasis.MRTFs- master regulators of EMT.A forceful connection: mechanoregulation of oncogenic YAP.TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism.
P2860
Q28833739-96197558-81A5-45E7-A901-8FA7BFCA0FF1Q30008747-E4EF54A3-A26B-4FFF-B839-077E6CD12FBFQ33634664-3CEFC33E-4841-47AC-ADD3-1A91A65F4E57Q36203073-521E3906-A3D4-4F6A-8059-516D394A35E8Q38696838-1B6C0864-EEC5-4E2C-B125-45F64BCD0315Q38724065-ADC585E8-9689-4F97-8228-E037A6825D88Q39417565-F12EAA6E-A109-46CC-9DCB-1446CBBAC20EQ48099760-1A75EAE0-C396-41AC-A616-D05281168FD4Q50431861-019F910A-473A-4BBC-B1F2-E0D6CA6D8356
P2860
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 11 February 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
@en
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells.
@nl
type
label
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
@en
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells.
@nl
prefLabel
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
@en
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells.
@nl
P2093
P2860
P356
P1433
P1476
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
@en
P2093
Aleksandra Toloczko
Fusheng Guo
Siew Wee Chan
Wanjin Hong
P2860
P304
13706-13716
P356
10.18632/ONCOTARGET.7333
P407
P577
2016-03-01T00:00:00Z