TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. - Wikidata - awgldk - TriplyDB

TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

http://www.wikidata.org/entity/Q37048061

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Radiotherapy combination opportunities leveraging immunity for the next oncology practice DNA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance Improving the efficacy of chemoradiation with targeted agents Combining radiotherapy and cancer immunotherapy: a paradigm shift The optimal partnership of radiation and immunotherapy: from preclinical studies to clinical translation Lung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasiveness Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma.Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.Proton irradiation augments the suppression of tumor progression observed with advanced age.TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity.Targeting the TGFβ signalling pathway in disease.Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.Inhibiting TGFβ1 has a protective effect on mouse bone marrow suppression following ionizing radiation exposure in vitro Trial Watch: Immunotherapy plus radiation therapy for oncological indications.A CCL8 gradient drives breast cancer cell dissemination.Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor.The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications.Redox-mediated and ionizing-radiation-induced inflammatory mediators in prostate cancer development and treatment.Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer.Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas.An unconventional role of BMP-Smad1 signaling in DNA damage response: a mechanism for tumor suppression.Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology.Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability.Portrait of inflammatory response to ionizing radiation treatment.Combining immunotherapy with radiation for the treatment of glioblastoma.The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer.Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression.Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway.Development of a novel multiplexed assay for quantification of transforming growth factor-β (TGF-β).TGF-β1 mediates the radiation response of prostate cancer.Thymoquinone restores radiation-induced TGF-β expression and abrogates EMT in chemoradiotherapy of breast cancer cells.

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TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

http://www.wikidata.org/entity/Q37048061

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bilimsel makale

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scientific article published on 25 October 2011

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vedecký článok

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TGFβ1 inhibition increases the ...... control by radiation in vivo.

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1078-0432.CCR-11-0544

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Clinical Cancer Research

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TGFβ1 inhibition increases the ...... r control by radiation in vivo

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Anupama Pal

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Byron Hann

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Fanny Bouquet

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J Keith DeWyngaert

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Jim S Babb

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Karsten A Pilones

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Mary Helen Barcellos-Hoff

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Rosemary J Akhurst

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Scott M Lonning

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Silvia C Formenti

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P2860

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

ATM associates with and phosphorylates p53: mapping the region of interaction.

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.

Halofuginone enhances the radiation sensitivity of human tumor cell lines

TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?

Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

Gene expression profiling of breast cell lines identifies potential new basal markers.

Malignant cells, directors of the malignant process: role of transforming growth factor-beta.

Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

The predictive role of plasma TGF-beta1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer.

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6754-6765

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10.1158/1078-0432.CCR-11-0544

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2011-10-25T00:00:00Z

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22028490

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