HLA-associated clinical progression correlates with epitope reversion rates in early human immunodeficiency virus infection
about
Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants.Modelling the evolution and spread of HIV immune escape mutantsCTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitopeHLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infectionHIV-1 vaccine development after STEP.Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virusAnalysis of HLA A*02 association with vaccine efficacy in the RV144 HIV-1 vaccine trial.Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infectionFluidity of HIV-1-specific T-cell responses during acute and early subtype C HIV-1 infection and associations with early disease progression.Early immune adaptation in HIV-1 revealed by population-level approaches.HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice.Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.Structured observations reveal slow HIV-1 CTL escape.Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processesGenotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection.Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: An overview of the possible applications.Conservation of HIV-1 T cell epitopes across time and clades: validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccinePopulation-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American EpidemicLow level of HIV-1 evolution after transmission from mother to child.HLA B51 is associated with faster AIDS progression among newly diagnosed HIV-infected individuals in Manitoba, Canada.Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.Rapid human immunodeficiency virus disease progression is associated with human leukocyte antigen-B homozygocity and human leukocyte antigen-B51 in a cohort from Manitoba, Canada.Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification.Further progress on defining highly conserved immunogenic epitopes for a global HIV vaccine: HLA-A3-restricted GAIA vaccine epitopes
P2860
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P2860
HLA-associated clinical progression correlates with epitope reversion rates in early human immunodeficiency virus infection
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
HLA-associated clinical progre ...... munodeficiency virus infection
@en
HLA-associated clinical progre ...... unodeficiency virus infection.
@nl
type
label
HLA-associated clinical progre ...... munodeficiency virus infection
@en
HLA-associated clinical progre ...... unodeficiency virus infection.
@nl
prefLabel
HLA-associated clinical progre ...... munodeficiency virus infection
@en
HLA-associated clinical progre ...... unodeficiency virus infection.
@nl
P2093
P2860
P356
P1433
P1476
HLA-associated clinical progre ...... munodeficiency virus infection
@en
P2093
A J Frater
A R McLean
L Lee-Turner
M Carrington
N Robinson
R E Phillips
P2860
P304
P356
10.1128/JVI.01545-08
P407
P50
P577
2008-11-19T00:00:00Z