Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus.
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M2e-Based Universal Influenza A VaccinesM2 protein from influenza A: from multiple structures to biophysical and functional insightsStructural basis for the function and inhibition of an influenza virus proton channelStructure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virusStructural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza virusesHigh-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transductionVoltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) familyComputational analysis of membrane proteins: the largest class of drug targets.Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.Modeling and simulation of ion channels.Structural basis for proton conduction and inhibition by the influenza M2 protein.Conformational heterogeneity of the M2 proton channel and a structural model for channel activationConformational changes of an ion channel detected through water-protein interactions using solid-state NMR spectroscopy.Theoretical frameworks for multiscale modeling and simulationMechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMRA theory for the proton transport of the influenza virus M2 protein: extensive test against conductance dataMultiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel.Proton Transport Mechanism of M2 Proton Channel Studied by Laser-Induced pH JumpDiffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site.NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel.Where does amantadine bind to the influenza virus M2 proton channel?Kinetics of proton transport into influenza virions by the viral M2 channel.Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virusVoltage-gated proton channels.Multiple Proton Confinement in the M2 Channel from the Influenza A VirusPhotoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channelTidal surge in the M2 proton channel, sensed by 2D IR spectroscopy.A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 proteinEffect of cytosolic pH on inward currents reveals structural characteristics of the proton transport cycle in the influenza A protein M2 in cell-free membrane patches of Xenopus oocytesHydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors.A peptide's perspective of water dynamicsGPU/CPU Algorithm for Generalized Born/Solvent-Accessible Surface Area Implicit Solvent Calculations.Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular SimulationsIdentification of the functional core of the influenza A virus A/M2 proton-selective ion channelActivation and proton transport mechanism in influenza A M2 channelAcid activation mechanism of the influenza A M2 proton channel.Interaction and conformational dynamics of membrane-spanning protein helices.On the role of water density fluctuations in the inhibition of a proton channel
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Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Molecular dynamics calculation ...... hannel from influenza A virus.
@en
Molecular dynamics calculation ...... hannel from influenza A virus.
@nl
type
label
Molecular dynamics calculation ...... hannel from influenza A virus.
@en
Molecular dynamics calculation ...... hannel from influenza A virus.
@nl
prefLabel
Molecular dynamics calculation ...... hannel from influenza A virus.
@en
Molecular dynamics calculation ...... hannel from influenza A virus.
@nl
P2093
P2860
P356
P1476
Molecular dynamics calculation ...... hannel from influenza A virus.
@en
P2093
Ekta Khurana
Matteo Dal Peraro
Michael L Klein
Russell DeVane
Satyavani Vemparala
P2860
P304
P356
10.1073/PNAS.0811720106
P407
P577
2009-01-14T00:00:00Z