Ras nanoclusters: combining digital and analog signaling.
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Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loopHierarchical nanostructure and synergy of multimolecular signalling complexes.Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity controlComputational properties of mitochondria in T cell activation and fateA functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in DrosophilaBiological robustness: paradigms, mechanisms, and systems principlesBiophysical mechanism for ras-nanocluster formation and signaling in plasma membranePalmitoylation of oncogenic NRAS is essential for leukemogenesis.Dynamic multiprotein assemblies shape the spatial structure of cell signalingFunctional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.Ras trafficking, localization and compartmentalized signallingOverview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Plasma membrane regulates Ras signaling networks.Activation of the MAPK module from different spatial locations generates distinct system outputs.Tetraspanin CD82 Regulates the Spatiotemporal Dynamics of PKCα in Acute Myeloid LeukemiaUsing plasma membrane nanoclusters to build better signaling circuitsUse of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cellsLessons from computer simulations of Ras proteins in solution and in membraneRas acylation, compartmentalization and signaling nanoclusters (Review).Compartmentalized signalling: Ras proteins and signalling nanoclusters.The spatial structure of cell signaling systems.Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction.Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.Optical sensors to gain mechanistic insights into signaling assemblies.Ras nanoclusters: a new drug target?KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputsDigital kinases: A cell model for sensing, integrating and making choices.Segregation of negatively charged phospholipids by the polycationic and farnesylated membrane anchor of Kras.Visualization of BRI1 and SERK3/BAK1 Nanoclusters in Arabidopsis Roots.N-Ras forms dimers at POPC membranes.Classification of dynamical diffusion states in single molecule tracking microscopy.Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.RAS variant signalling
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P2860
Ras nanoclusters: combining digital and analog signaling.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 26 October 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Ras nanoclusters: combining digital and analog signaling.
@en
Ras nanoclusters: combining digital and analog signaling.
@nl
type
label
Ras nanoclusters: combining digital and analog signaling.
@en
Ras nanoclusters: combining digital and analog signaling.
@nl
prefLabel
Ras nanoclusters: combining digital and analog signaling.
@en
Ras nanoclusters: combining digital and analog signaling.
@nl
P2860
P356
P1433
P1476
Ras nanoclusters: combining digital and analog signaling.
@en
P2093
Angus Harding
John F Hancock
P2860
P304
P356
10.4161/CC.7.2.5237
P577
2007-10-26T00:00:00Z