Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
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Click chemistry in peptide-based drug designRapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequenceHuprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallographySpatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click ChemistryTether influence on the binding properties of tRNALys3 ligands designed by a fragment-based approach."Click" reaction in conjunction with diazeniumdiolate chemistry: developing high-load nitric oxide donors.Synthesis of small molecules targeting multiple DNA structures using click chemistry.CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitorsOne-pot three-step synthesis of 1,2,3-triazoles by copper-catalyzed cycloaddition of azides with alkynes formed by a Sonogashira cross-coupling and desilylation.Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.Copper-catalyzed azide-alkyne cycloaddition: regioselective synthesis of 1,4,5-trisubstituted 1,2,3-triazoles.Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation.Macroporous polymer supported azide and nanocopper (I): efficient and reusable reagent and catalyst for multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from benzyl halides.Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale productionCu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.New CD1d agonists: synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides.Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE.Marinopyrrole A target elucidation by acyl dye transfer.C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.Alkyne-azide cycloadditions with copper powder in a high-pressure continuous-flow reactor: high-temperature conditions versus the role of additives.Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands.Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.Bifunctional Diaminoterephthalate Fluorescent Dye as Probe for Cross-Linking Proteins.Coupling of Ligands to the Liposome Surface by Click Chemistry.A facile and one pot synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from terminal alkynes and phenacyl azides prepared from styrenes by CAN oxidant and sodium azide.An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles.Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imaging.Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virusMultifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry
P2860
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P2860
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@en
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@nl
type
label
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@en
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@nl
prefLabel
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@en
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@nl
P356
P1433
P1476
Click chemistry and medicinal chemistry: a case of "cyclo-addiction".
@en
P2093
A D Moorhouse
P304
P356
10.1002/CMDC.200700334
P577
2008-05-01T00:00:00Z