Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.
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5'-UTR RNA G-quadruplexes: translation regulation and targetingOverexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescenceMonomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural studyDo we know whether potential G-quadruplexes actually form in long functional RNA molecules?Environmental immune disruptors, inflammation and cancer riskAlternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.Targeting human telomerase for cancer therapeutics.U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence.QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs.Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivityFluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligandsOptimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex.Development of squaraine based G-quadruplex ligands using click chemistryNucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNAStructural insights into G-quadruplexes: towards new anticancer drugs.Regulation of the human catalytic subunit of telomerase (hTERT).A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcriptsSuppression of gene expression by G-quadruplexes in open reading frames depends on G-quadruplex stability.Evolutionarily emerged G tracts between the polypyrimidine tract and 3' AG are splicing silencers enriched in genes involved in cancer.G-quadruplexes: from guanine gels to chemotherapeuticsThe DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzymeTelomeres, telomerase, and apoptosis.Telomeric G-quadruplexes are a substrate and site of localization for human telomeraseTelomerase: a potential therapeutic target for cancer.Computational Analysis of G-Quadruplex Forming Sequences across Chromosomes Reveals High Density Patterns Near the Terminal Ends.Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityQuantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cellsThe high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA.Telomerase inhibition in cancer therapeutics: molecular-based approachesHybridization of complementary and homologous peptide nucleic acid oligomers to a guanine quadruplex-forming RNAExploring mRNA 3'-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shorteningPyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cellsDNA secondary structures: stability and function of G-quadruplex structures.A hitchhiker's guide to G-quadruplex ligands.Mechanism of HIV-1 RNA dimerization in the central region of the genome and significance for viral evolution.Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands.Genome-wide colonization of gene regulatory elements by G4 DNA motifsStructure-function relationships in telomerase genes.
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Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Telomerase downregulation indu ...... TERT RNA alternative splicing.
@en
Telomerase downregulation indu ...... TERT RNA alternative splicing.
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type
label
Telomerase downregulation indu ...... TERT RNA alternative splicing.
@en
Telomerase downregulation indu ...... TERT RNA alternative splicing.
@nl
prefLabel
Telomerase downregulation indu ...... TERT RNA alternative splicing.
@en
Telomerase downregulation indu ...... TERT RNA alternative splicing.
@nl
P2093
P2860
P50
P356
P1476
Telomerase downregulation indu ...... hTERT RNA alternative splicing
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P2093
Dennis Gomez
Patrick Mailliet
Thibault Lemarteleur
P2860
P304
P356
10.1093/NAR/GKH181
P407
P577
2004-01-16T00:00:00Z