Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?
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Extending healthy life span--from yeast to humansSHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegansMicroRNA predictors of longevity in Caenorhabditis elegansLongevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intakeRibosomal protein S6 kinase 1 signaling regulates mammalian life spanShould we treat aging as a disease? The consequences and dangers of miscategorisation.Small is beautiful: insulin-like growth factors and their role in growth, development, and cancerRunning on empty: how p53 controls INS/IGF signaling and affects life spanRNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutationsMechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.The new biology of ageing.Growth factors, aging and age-related diseases.Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network.The somatotropic axis and aging: mechanisms and persistent questions about practical implications.Mammalian models of extended healthy lifespan.Dissecting molecular stress networks: identifying nodes of divergence between life-history phenotypes.Health-and disease-related biomarkers in aging research.Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels.Lifespan modulation in mice and the confounding effects of genetic background.Computational modelling of the regulation of Insulin signalling by oxidative stress.Linking nutrition, maturation and aging: from thrifty genes to the spendthrift phenotypeGenome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signallingUsing doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster.Increased Akt signaling in the mosquito fat body increases adult survivorship.Metabotyping of long-lived mice using 1H NMR spectroscopyAging genetics and aging.Gender Differences in Response to Prolonged Every-Other-Day Feeding on the Proliferation and Apoptosis of Hepatocytes in MiceInsulin signalling mediates the response to male-induced harm in female Drosophila melanogasterMolecular mechanisms of aging and immune system regulation in Drosophila.The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice.IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevityLongevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage.The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila.Detoxification reactions: relevance to aging.High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research.
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Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Separating cause from effect: ...... span in worms, flies and mice?
@en
Separating cause from effect: ...... span in worms, flies and mice?
@nl
type
label
Separating cause from effect: ...... span in worms, flies and mice?
@en
Separating cause from effect: ...... span in worms, flies and mice?
@nl
prefLabel
Separating cause from effect: ...... span in worms, flies and mice?
@en
Separating cause from effect: ...... span in worms, flies and mice?
@nl
P50
P1476
Separating cause from effect: ...... span in worms, flies and mice?
@en
P2093
J J McElwee
P304
P356
10.1111/J.1365-2796.2007.01906.X
P407
P577
2008-02-01T00:00:00Z