Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.
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Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondLongevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intakeDepletion of Rictor, an essential protein component of mTORC2, decreases male lifespanBig mice die young but large animals live longerThe GH/IGF-1 axis in ageing and longevityThe key role of growth hormone-insulin-IGF-1 signaling in aging and cancerGene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.Diminished mTOR signaling: a common mode of action for endocrine longevity factors.Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress.Increased Akt signaling in the mosquito fat body increases adult survivorship.Metabotyping of long-lived mice using 1H NMR spectroscopyDiverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.Rejuvenating immunity: "anti-aging drug today" eight years later.Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.Mini-review: Retarding aging in murine genetic models of neurodegenerationIGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevityLong-term p110α PI3K inactivation exerts a beneficial effect on metabolismLongevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage.Probing the relationship between insulin sensitivity and longevity using genetically modified miceRapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.Dietary restriction and the pursuit of effective mimetics.Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition.Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort.Membrane ion Channels and Receptors in Animal lifespan Modulation.The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.Somatic growth, aging, and longevity.Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.TOR-mediated regulation of metabolism in aging.Caloric restriction can improve learning ability in C57/BL mice via regulation of the insulin-PI3K/Akt signaling pathway.Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway.Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice.Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice.Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells
P2860
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P2860
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Replication of extended lifesp ...... insulin receptor substrate 1.
@ast
Replication of extended lifesp ...... insulin receptor substrate 1.
@en
type
label
Replication of extended lifesp ...... insulin receptor substrate 1.
@ast
Replication of extended lifesp ...... insulin receptor substrate 1.
@en
prefLabel
Replication of extended lifesp ...... insulin receptor substrate 1.
@ast
Replication of extended lifesp ...... insulin receptor substrate 1.
@en
P2860
P50
P1433
P1476
Replication of extended lifesp ...... insulin receptor substrate 1.
@en
P2860
P304
P356
10.1371/JOURNAL.PONE.0016144
P407
P577
2011-01-25T00:00:00Z