Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain
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Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activityMechanisms of chiral discrimination by topoisomerase IVA novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation.The dynamic interplay between DNA topoisomerases and DNA topology.Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA.The use of divalent metal ions by type II topoisomerases.The tail that wags the dog: topoisomerase IV ParC C-terminal domain controls strand passage activity through multipartite topology-dependent interactions with DNA.Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismThe geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase IInteractions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageE. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.Mechanisms for defining supercoiling set point of DNA gyrase orthologs: I. A nonconserved acidic C-terminal tail modulates Escherichia coli gyrase activity.Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomeraseAntileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90.Topoisomerase II and leukemia.Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domainTopoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage.Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.Understanding the role of domain-domain linkers in the spatial orientation of domains in multi-domain proteins.Activities of gyrase and topoisomerase IV on positively supercoiled DNA.The Dynamic Interplay Between DNA Topoisomerases and DNA Topology.Interaction of silver atomic quantum clusters with living organisms: bactericidal effect of Ag3 clusters mediated by disruption of topoisomerase-DNA complexes.Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain.
P2860
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P2860
Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain
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article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on December 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Bimodal recognition of DNA geo ...... ments in the C-terminal domain
@en
Bimodal recognition of DNA geo ...... ents in the C-terminal domain.
@nl
type
label
Bimodal recognition of DNA geo ...... ments in the C-terminal domain
@en
Bimodal recognition of DNA geo ...... ents in the C-terminal domain.
@nl
prefLabel
Bimodal recognition of DNA geo ...... ments in the C-terminal domain
@en
Bimodal recognition of DNA geo ...... ents in the C-terminal domain.
@nl
P2093
P2860
P356
P1433
P1476
Bimodal recognition of DNA geo ...... ments in the C-terminal domain
@en
P2093
A Kathleen McClendon
Amanda C Gentry
Anni H Andersen
Jennifer S Dickey
Marie Brinch
Neil Osheroff
Simon Bendsen
P2860
P304
13169-13178
P356
10.1021/BI800453H
P407
P577
2008-12-01T00:00:00Z