Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027
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A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathwayNew Insights into the Mechanism of Enzymatic Chlorination of TryptophanStructural Insights into Regioselectivity in the Enzymatic Chlorination of TryptophanCrystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.Unusual flavoenzyme catalysis in marine bacteria.Biosynthesis of enediyne antitumor antibioticsEnzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.Independent Evolution of Six Families of Halogenating Enzymes.Explorations of catalytic domains in non-ribosomal peptide synthetase enzymologyA free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis.Structural perspective on enzymatic halogenation.Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.PKS and NRPS release mechanisms.Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.Biosynthesis of natural products containing β-amino acids.A Fivefold Parallelized Biosynthetic Process Secures Chlorination of Armillaria mellea (Honey Mushroom) Toxins.Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo.Enzymatic Halogenation: A Timely Strategy for Regioselective C-H Activation.Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesisSpecificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248.Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins.Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis.Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities
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P2860
Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 September 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Regiospecific chlorination of ...... ne antitumor antibiotic C-1027
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Regiospecific chlorination of
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type
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Regiospecific chlorination of ...... ne antitumor antibiotic C-1027
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Regiospecific chlorination of
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prefLabel
Regiospecific chlorination of ...... ne antitumor antibiotic C-1027
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Regiospecific chlorination of
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P2860
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P1476
Regiospecific chlorination of ...... ne antitumor antibiotic C-1027
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Shuangjun Lin
Steven G Van Lanen
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P304
12432-12438
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10.1021/JA072311G
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P577
2007-09-22T00:00:00Z