PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model. - Wikidata - awgldk - TriplyDB

PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.

PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.

http://www.wikidata.org/entity/Q37076589

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Treating brain tumors with PDE4 inhibitors Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases Permeability imaging in pediatric brain tumors.Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes Advances in targeting cyclic nucleotide phosphodiesterases Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs.Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.Roles of sildenafil in enhancing drug sensitivity in cancer.HSPA5/Dna K may be a useful target for human disease therapies.PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies Nexavar/Stivarga and viagra interact to kill tumor cells.GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.Gold nanoparticle imaging and radiotherapy of brain tumors in mice.Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants.Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function Pharmacological modulation of cytotoxicity and cellular uptake of anti-cancer drugs by PDE5 inhibitors in lung cancer cells Immune-checkpoint blockade and active immunotherapy for glioma.Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis.Targeting cancer with phosphodiesterase inhibitors.Clinical and molecular genetics of the phosphodiesterases (PDEs).Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome.Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier.Overcoming in vivo barriers to targeted nanodelivery.Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors.Blood-brain barrier permeation and efflux exclusion of anticholinergics used in the treatment of overactive bladder.Strategies for overcoming the blood-brain barrier for the treatment of brain metastases.The role of cGMP and its signaling pathways in kidney disease.Phosphodiesterase type 5 inhibitor Tadalafil increases Rituximab treatment efficacy in a mouse brain lymphoma model.Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study.Systemic treatment of brain metastases in HER2-positive breast cancer: current status and future directions.Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer.Phosphodiesterase type 5 and cancers: progress and challenges.

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PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.

http://www.wikidata.org/entity/Q37076589

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article científic

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bilimsel makale

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scientific article published on 14 July 2008

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vedecký článok

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vetenskaplig artikel

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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J.BRAINRES.2008.06.122

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PDE5 inhibitors enhance tumor ...... py in a rat brain tumor model.

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Andreas Espinoza

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Bindu M Konda

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Dali Yin

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Dwain K Irvin

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Jennifer-Ann Bayan

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Jinwei Hu

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John M Ong

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Keith L Black

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Manuel R Sacapano

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MinHee K Ko

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P2860

Phosphodiesterases in the CNS: targets for drug development

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973-1991.

Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy

Cyclic GMP phosphodiesterase-5: target of sildenafil.

Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier.

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats.

The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery.

Albondin-mediated capillary permeability to albumin. Differential role of receptors in endothelial transcytosis and endocytosis of native and modified albumins.

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).

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10.1016/J.BRAINRES.2008.06.122

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