Targeting cancer with phosphodiesterase inhibitors. - Wikidata - awgldk - TriplyDB

Targeting cancer with phosphodiesterase inhibitors.

Targeting cancer with phosphodiesterase inhibitors.

http://www.wikidata.org/entity/Q37650389

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Treating brain tumors with PDE4 inhibitors Penile rehabilitation after radical prostatectomy: does it work?Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis Inhibition of Phosphodiesterase 5 and Increasing the Level of Cyclic Guanosine 3',5' Monophosphate by Hydroalcoholic Achillea wilhelmsii C. Koch Extract in Human Breast Cancer Cell Lines MCF-7 and MDA-Mb-468.Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model Cyclic AMP, protein kinase A, and phosphodiesterases: proceedings of an international workshop Carnosic acid inhibits the epithelial-mesenchymal transition in B16F10 melanoma cells: a possible mechanism for the inhibition of cell migration.A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.Advances in targeting cyclic nucleotide phosphodiesterases Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468.PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1.Cyclic phosphatidic acid stimulates cAMP production and inhibits growth in human colon cancer cells.Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).Houttuynia cordata Thunb extract modulates G0/G1 arrest and Fas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatment The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.Regulation of the Hippo pathway and implications for anticancer drug development.Clinical and molecular genetics of the phosphodiesterases (PDEs).cAMP signaling increases histone deacetylase 8 expression via the Epac2-Rap1A-Akt pathway in H1299 lung cancer cells.The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases.Platelet-targeted pharmacologic treatments as anti-cancer therapy.Vinpocetine inhibits breast cancer cells growth in vitro and in vivo.Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.t(4;8)(q27;q24) in Hodgkin lymphoma cells targets phosphodiesterase PDE5A and homeobox gene ZHX2.Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia.The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP.RAF-isotype switching: from B to C through PDE.A small molecule screen to identify regulators of let-7 targets.Phosphodiesterase type 5 and cancers: progress and challenges.Roflumilast restores cAMP/PKA/CREB signaling axis for FtMt-mediated tumor inhibition of ovarian cancer.Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival.A novel computational approach for drug repurposing using systems biology.Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function.

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Targeting cancer with phosphodiesterase inhibitors.

http://www.wikidata.org/entity/Q37650389

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on January 2010

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Targeting cancer with phosphodiesterase inhibitors.

@en

Targeting cancer with phosphodiesterase inhibitors.

@nl

type

label

Targeting cancer with phosphodiesterase inhibitors.

@en

Targeting cancer with phosphodiesterase inhibitors.

@nl

prefLabel

Targeting cancer with phosphodiesterase inhibitors.

@en

Targeting cancer with phosphodiesterase inhibitors.

@nl

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Expert Opinion on Investigational Drugs

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Targeting cancer with phosphodiesterase inhibitors.

@en

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Friedrich Grimminger

http://www.w3.org/2001/XMLSchema#string

Gamal-Andre Banat

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Hossein Ardeschir Ghofrani

http://www.w3.org/2001/XMLSchema#string

Norbert Weissmann

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Rajkumar Savai

http://www.w3.org/2001/XMLSchema#string

Ralph Theo Schermuly

http://www.w3.org/2001/XMLSchema#string

Soni Savai Pullamsetti

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P2860

The Hallmarks of Cancer

Identification of human PDE7B, a cAMP-specific phosphodiesterase

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation

PDE4 inhibitors: current status

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

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117-131

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scholarly article

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10.1517/13543780903485642

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1

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19

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2010-01-01T00:00:00Z

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40679526

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20001559

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