Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
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Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase CβNKX2-5, a modifier of skeletal muscle pathology due to RNA toxicity.Mechanistic determinants of MBNL activityAutoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.MBNL proteins and their target RNAs, interaction and splicing regulation.Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.Two enhancers control transcription of Drosophila muscleblind in the embryonic somatic musculature and in the central nervous system.MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy BrainMuscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation.A flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I.Conservation of context-dependent splicing activity in distant Muscleblind homologsCompound loss of muscleblind-like function in myotonic dystrophy.The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1.Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy.RNA Sequence Context Effects Measured In Vitro Predict In Vivo Protein Binding and RegulationDisrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.MBNL expression in autoregulatory feedback loops.A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1.miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.
P2860
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P2860
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Progressive impairment of musc ...... -like 3 isoform knockout mice.
@en
Progressive impairment of musc ...... -like 3 isoform knockout mice.
@nl
type
label
Progressive impairment of musc ...... -like 3 isoform knockout mice.
@en
Progressive impairment of musc ...... -like 3 isoform knockout mice.
@nl
prefLabel
Progressive impairment of musc ...... -like 3 isoform knockout mice.
@en
Progressive impairment of musc ...... -like 3 isoform knockout mice.
@nl
P2093
P2860
P50
P356
P1476
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice
@en
P2093
Chaolin Zhang
Michael G Poulos
P2860
P304
P356
10.1093/HMG/DDT209
P577
2013-05-08T00:00:00Z