Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes.
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Pituitary somatostatin receptor signalingFemale Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies.The neuroendocrine functions of the parathyroid hormone 2 receptorSomatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice.Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.Constitutive somatostatin receptor activity determines tonic pituitary cell response.Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.Maternal obesity programs reduced leptin signaling in the pituitary and altered GH/IGF1 axis function leading to increased adiposity in adult sheep offspring.Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.Effects of high-altitude hypoxia on the hormonal response to hypothalamic factors.Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.Association between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and hypertension.
P2860
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P2860
Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 December 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of endogenous somatostati ...... esponse to metabolic extremes.
@en
Role of endogenous somatostati ...... esponse to metabolic extremes.
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type
label
Role of endogenous somatostati ...... esponse to metabolic extremes.
@en
Role of endogenous somatostati ...... esponse to metabolic extremes.
@nl
prefLabel
Role of endogenous somatostati ...... esponse to metabolic extremes.
@en
Role of endogenous somatostati ...... esponse to metabolic extremes.
@nl
P1476
Role of endogenous somatostati ...... response to metabolic extremes
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P2093
Seungjoon Park
P304
P356
10.1016/J.MCE.2007.12.005
P577
2007-12-14T00:00:00Z