about
Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary functionMetabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropesTargeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse modelSomatostatin and its receptors from fish to mammals.Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed miceA mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.Research progress in the stimulatory inputs regulating growth hormone (GH) secretion.Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primatesObesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin.Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomasKisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanismsRole of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).New insights in the mechanism by which SRIF influences GH secretion.Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parametersMolecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of AcromegalyIn1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features.The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female miceLack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes.Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.Expression analysis of dopamine receptor subtypes in normal human pituitaries, nonfunctioning pituitary adenomas and somatotropinomas, and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acromeBoth estrogen receptor α and β stimulate pituitary GH gene expression.Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients.Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice.Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Raul M Luque
@ast
Raul M Luque
@en
Raul M Luque
@es
Raul M Luque
@nl
type
label
Raul M Luque
@ast
Raul M Luque
@en
Raul M Luque
@es
Raul M Luque
@nl
prefLabel
Raul M Luque
@ast
Raul M Luque
@en
Raul M Luque
@es
Raul M Luque
@nl
P108
P106
P21
P31
P496
0000-0002-7585-1913