Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. - Wikidata - awgldk - TriplyDB

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

http://www.wikidata.org/entity/Q37082114

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Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system.Chemical probes of endocannabinoid metabolism A lipid gate for the peripheral control of pain A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation Peripheral gating of pain signals by endogenous lipid mediators.Acute Δ(9)-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models.Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides.Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice Endocannabinoid signaling at the periphery: 50 years after THC.Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes.Endogenous N-acyl taurines regulate skin wound healing.Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain.Anandamide in primary sensory neurons: too much of a good thing?No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids.The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.COX inhibitors: a patent review (2011 - 2014).Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine.Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis.

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Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

http://www.wikidata.org/entity/Q37082114

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 07 March 2012

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

@en

Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

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type

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Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

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Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

@nl

prefLabel

Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

@en

Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

@nl

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J.PHRS.2012.02.012

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Pharmacological Research

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Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.

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Andrea Armirotti

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Angelo Reggiani

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Daniele Piomelli

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Giampiero Colombano

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Guillermo Moreno-Sanz

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Oscar Sasso

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Rita Scarpelli

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Rosalia Bertorelli

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Tiziano Bandiera

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P2860

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

The molecular logic of endocannabinoid signalling

Modulation of anxiety through blockade of anandamide hydrolysis

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.

The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.

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10.1016/J.PHRS.2012.02.012

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2012-03-07T00:00:00Z

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22420940

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