The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice - Wikidata - awgldk - TriplyDB

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

http://www.wikidata.org/entity/Q28296777

about

The pharmacological landscape and therapeutic potential of serine hydrolases Structure-guided inhibitor design for human FAAH by interspecies active site conversion Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders Enzymatic pathways that regulate endocannabinoid signaling in the nervous system Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects.Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.Endocannabinoid overload Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models.β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine.A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo Identification of prostamides, fatty acyl ethanolamines, and their biosynthetic precursors in rabbit cornea.A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects.The endocannabinoid system and pain Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms.Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.A catalytically silent FAAH-1 variant drives anandamide transport in neurons.Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy.Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics follo

P2860

Q26995817-27872055-484C-4D10-90A8-E06AF5BB94DF Q27651822-1BD8946A-5627-46E0-A083-6739AC6D6858 Q27655121-2D08BA6B-DB3C-4246-887D-9270E69D949C Q27661834-56B559FC-E8F6-4570-AFCB-E97D1E723022 Q28262282-F8BA4DC3-4F65-499C-A36C-E92C76AB055B Q28285103-C3DA10CA-2CCE-4072-A896-3782B679F393 Q28390932-8776F381-8F01-42AF-A564-1FCB886CDB82 Q28548007-8FDFF60C-90E1-4EDD-93FC-D0B53D0AEA8B Q28575056-2C97D3F4-0D33-4273-9CF9-01370FCF039E Q30492114-817F64C5-98F4-4FAB-8030-57C8B305A892 Q30733453-42A00DE5-4EF9-4A16-9DAE-973A81011684 Q33560467-9FEE1801-A3BF-44CE-B30F-0B7EF0F05600 Q34019573-199281EA-7CF9-4B9A-81A2-56D794862279 Q34029257-D736070E-17E2-48FA-B037-4FFDBA19F6F6 Q34101852-8A9CF662-BBCE-45E2-8306-A986A882CB10 Q34144131-AB2AA7E8-E702-43F6-8022-1CDBF776AD8B Q34179408-79131AFC-8028-4EEC-A1FA-E7A88CAD3582 Q34231719-408AD402-63EE-41F1-86E5-9F4E4681DDDA Q34390806-16EBDE5A-B9EE-4DEB-B7E6-266F538C8969 Q34423074-0691486A-C77D-4638-A1DC-3EF18BF41B1B Q34467166-987479E0-9876-4637-9164-E8D78C51D7C9 Q34478780-BEDD78A8-B532-4B7F-B8B1-E4A8D8543E04 Q34479599-B052E477-E165-4B32-9BC2-4076F1AE8C98 Q34496064-E9697949-206A-4BEC-A0CD-AF76D903707D Q34612917-7403716B-D6FD-4DDC-8981-05877DB79F22 Q34801735-0AD01183-FB73-4826-88D1-070F11E37AE3 Q34953319-70CCFCD5-B580-46B3-AAD3-B73672B7B468 Q35189004-60BDE9F9-F5C8-469E-8893-005F4D934701 Q35202878-2763B72C-CA2A-4240-9568-94677BAB0A37 Q35223920-0D93B5E7-9766-444D-B210-12C5A02ABBBC Q35532072-40DDEC11-1F25-47CC-B485-A356313046CE Q35633097-4F74536C-BCCA-4850-917E-CCC49B58CE11 Q35678770-1721BD56-436B-4E46-98F4-8264AB0470CF Q35689152-1DBC7261-5FFC-4DD8-9017-03612A0848C1 Q36006338-7F4C17E1-A79B-4B0D-872C-5321F551E6EA Q36057960-FA16B846-3495-4759-AEF1-25AB46EC2C46 Q36176531-47502613-7D70-41F9-9B06-6E8B06362E67 Q36223310-EA87730F-C69A-4E4A-9FF9-0CFDFEDFE9D5 Q36455289-18D3ABF0-89FF-4FEA-B345-F8A5CE6E9292 Q36476481-6E06FA74-D503-46C6-B0F5-66A246ECECA5

P2860

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

http://www.wikidata.org/entity/Q28296777

description

2007 nî lūn-bûn

@nan

2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

The fatty acid amide hydrolase ...... er oral administration in mice

@ast

The fatty acid amide hydrolase ...... er oral administration in mice

@en

The fatty acid amide hydrolase ...... er oral administration in mice

@nl

type

label

The fatty acid amide hydrolase ...... er oral administration in mice

@ast

The fatty acid amide hydrolase ...... er oral administration in mice

@en

The fatty acid amide hydrolase ...... er oral administration in mice

@nl

prefLabel

The fatty acid amide hydrolase ...... er oral administration in mice

@ast

The fatty acid amide hydrolase ...... er oral administration in mice

@en

The fatty acid amide hydrolase ...... er oral administration in mice

@nl

P1433

Q28296777-C39967FD-2E13-46D9-BE68-117DA3D43AA5

P1476

Q28296777-9ECDA933-985E-44BE-BA4B-97D001EDAC61

P2093

Q28296777-2687F823-73B9-42FC-AB2F-D970A33D536C

Q28296777-31CE523B-682C-417F-B3FF-7525118B4268

Q28296777-3661254C-C120-4CE6-9E7E-40FC37870530

Q28296777-3A20D45E-3823-469A-85A6-A254D581EA8A

Q28296777-5935DCB1-90DC-4AF6-A2B4-A0E7C06774A7

Q28296777-BDC0502B-162A-454C-9C16-2F4A46B0725A

Q28296777-E4BFDBA1-3135-4D0B-8ACD-86CC2DC48EBA

Q28296777-EFE96EE1-1C7B-4B7A-9D8A-ABB53A2EA2AA

Q28296777-F032F82E-F635-4B46-9E36-9AAC7F221A2A

P304

Q28296777-23A7203D-7CD2-4C28-8963-EAC2EFE8DC05

P31

Q28296777-014346FA-0BF2-42CB-8AD4-5FEF1FBDED3D

P356

Q28296777-AB287F10-A45D-438F-9C14-5132130E522D

P407

Q28296777-956C886B-42FA-4A03-BAE5-0E0ECC011184

P433

Q28296777-9A5EB417-50FC-4A2A-ACCA-B619765F9A35

P478

Q28296777-FE51B76C-8861-4604-B707-BCD583C5FFEE

P50

Q28296777-2C79565C-9696-4CC3-9E85-F699B975F9A4

Q28296777-7B22AADA-7961-43A5-9608-42B2A45E26A3

P577

Q28296777-ED3FF2C6-1988-4680-9048-D6FD511BCFE7

P5875

Q28296777-088D54A0-F1B1-4904-B845-855197464F7B

P698

Q28296777-BF551BB0-07A7-418F-A36F-F2BD27B7D403

P921

Q28296777-52387EA7-AACB-462B-9C16-0E0C9FEB165B

Q28296777-66D3F235-B826-4A1A-A1B5-255EF4E4188E

P356

JPET.107.119941

P1433

Journal of Pharmacology and Experimental Therapeutics

P1476

The fatty acid amide hydrolase ...... er oral administration in mice

@en

P2093

Andrea Duranti

http://www.w3.org/2001/XMLSchema#string

Andrea Tontini

http://www.w3.org/2001/XMLSchema#string

Daniele Piomelli

http://www.w3.org/2001/XMLSchema#string

Giorgio Tarzia

http://www.w3.org/2001/XMLSchema#string

Giovanna La Rana

http://www.w3.org/2001/XMLSchema#string

Jeff Parrott

http://www.w3.org/2001/XMLSchema#string

Jesse Loverme

http://www.w3.org/2001/XMLSchema#string

Roberto Russo

http://www.w3.org/2001/XMLSchema#string

Timothy R Compton

http://www.w3.org/2001/XMLSchema#string

P304

236-242

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1124/JPET.107.119941

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

322

http://www.w3.org/2001/XMLSchema#string

P50

Antonio Calignano

P577

2007-04-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6408994

http://www.w3.org/2001/XMLSchema#string

P698

17412883

http://www.w3.org/2001/XMLSchema#string

P921

neuropathic pain