Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir
about
The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirusHuman cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment.A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.Human cytomegalovirus UL97 kinase alters the accumulation of CDK1.Novel biotinylated lipid prodrugs of acyclovir for the treatment of herpetic keratitis (HK): transporter recognition, tissue stability and antiviral activityThe genetic basis of human cytomegalovirus resistance and current trends in antiviral resistance analysis.Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.The search for new therapies for human cytomegalovirus infections.A Review of Functional Motifs Utilized by Viruses.Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.Novel Method Based on Real-Time Cell Analysis for Drug Susceptibility Testing of Herpes Simplex Virus and Human Cytomegalovirus.
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P2860
Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 21 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conserved retinoblastoma prote ...... ts susceptibility to maribavir
@en
Conserved retinoblastoma prote ...... s susceptibility to maribavir.
@nl
type
label
Conserved retinoblastoma prote ...... ts susceptibility to maribavir
@en
Conserved retinoblastoma prote ...... s susceptibility to maribavir.
@nl
prefLabel
Conserved retinoblastoma prote ...... ts susceptibility to maribavir
@en
Conserved retinoblastoma prote ...... s susceptibility to maribavir.
@nl
P2093
P2860
P356
P1433
P1476
Conserved retinoblastoma prote ...... ts susceptibility to maribavir
@en
P2093
Caroll B Hartline
Rachel B Gill
Samuel L Frederick
Sunwen Chou
P2860
P356
10.1186/1743-422X-6-9
P577
2009-01-21T00:00:00Z