Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. - Wikidata - awgldk - TriplyDB

Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.

Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.

http://www.wikidata.org/entity/Q36594113

about

The DNA damage response induced by infection with human cytomegalovirus and other viruses Recruitment of the oncoprotein v-ErbA to aggresomes.Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases Antiviral drug resistance of human cytomegalovirus.Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen.Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1 Innate nuclear sensor IFI16 translocates into the cytoplasm during the early stage of in vitro human cytomegalovirus infection and is entrapped in the egressing virions during the late stage.An epistatic relationship between the viral protein kinase UL97 and the UL133-UL138 latency locus during the human cytomegalovirus lytic cycle.An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus Efficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog.Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment.Overexpression of the transcriptional repressor complex BCL-6/BCoR leads to nuclear aggregates distinct from classical aggresomes A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication Progress in the development of new therapies for herpesvirus infections The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection Human cytomegalovirus pUL97 kinase induces global changes in the infected cell phosphoproteome.Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.Herpes simplex viruses: mechanisms of DNA replication.Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.Deficiencies in Cellular Processes Modulated by the Retinoblastoma Protein Do Not Account for Reduced Human Cytomegalovirus Replication in Its Absence Human cytomegalovirus UL97 kinase alters the accumulation of CDK1.The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97.Cell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus.Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding.Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir Regulation of the retinoblastoma proteins by the human herpesviruses.Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity.Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia The genetic basis of human cytomegalovirus resistance and current trends in antiviral resistance analysis.Tegument proteins of human cytomegalovirus Human Cytomegalovirus Can Procure Deoxyribonucleotides for Viral DNA Replication in the Absence of Retinoblastoma Protein Phosphorylation.Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.Congenital cytomegalovirus infection: molecular mechanisms mediating viral pathogenesis.

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P2860

Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.

http://www.wikidata.org/entity/Q36594113

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

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Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

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type

label

Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

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Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

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prefLabel

Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

@ast

Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

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Journal of Virology

P1476

Human cytomegalovirus UL97 kin ...... rmation of nuclear aggresomes.

@en

P2093

Amie L Perry

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Caroll B Hartline

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Daniel N Streblow

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Earl R Kern

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Elizabeth Sztul

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Mark N Prichard

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Rachel B Gill

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Richard D Smith

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Samuel L Frederick

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Shannon L Daily

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P2860

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

Ability of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cells

Simple and highly efficient BAC recombineering using galK selection

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells

The role of PML in tumor suppression

Aggresomes and autophagy generate sites for virus replication

The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1

Nuclear aggresomes form by fusion of PML-associated aggregates.

Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis

P304

5054-5067

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10.1128/JVI.02174-07

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10

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82

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2008-03-05T00:00:00Z

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5530329

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18321963

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Cytomegalovirus

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2346732

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