Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis - Wikidata - awgldk - TriplyDB

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

http://www.wikidata.org/entity/Q37086842

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The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions Shigella Diversity and Changing Landscape: Insights for the Twenty-First Century Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders Mucosal healing and deep remission: what does it mean?A refined palate: bacterial consumption of host glycans in the gut Keeping bugs in check: The mucus layer as a critical component in maintaining intestinal homeostasis Intestinal permeability--a new target for disease prevention and therapy CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis Dissecting the Interplay Between Intestinal Microbiota and Host Immunity in Health and Disease: Lessons Learned from Germfree and Gnotobiotic Animal Models Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease-Associated Diarrhea Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis Deep transcriptional sequencing of mucosal challenge compartment from rhesus macaques acutely infected with simian immunodeficiency virus implicates loss of cell adhesion preceding immune activation Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection.Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line Interaction of microbes with mucus and mucins: recent developments Microbiota-induced peritrophic matrix regulates midgut homeostasis and prevents systemic infection of malaria vector mosquitoes.Exploring the influence of the gut microbiota and probiotics on health: a symposium report.Microbiota activation and regulation of innate and adaptive immunity.Activation of epidermal growth factor receptor mediates mucin production stimulated by p40, a Lactobacillus rhamnosus GG-derived protein.Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer.The gastrointestinal mucus system in health and disease Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis Mucus and the goblet cell.B cells as a critical node in the microbiota-host immune system network.Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates Intestinal inflammation and mucosal barrier function.Microbiota organization is a distinct feature of proximal colorectal cancers The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine.Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut The composition of the gut microbiota throughout life, with an emphasis on early life.The composition of the gut microbiota shapes the colon mucus barrier.Gut ecosystem: how microbes help us.Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF-/- mice.Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis

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Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

http://www.wikidata.org/entity/Q37086842

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 20 February 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Bacteria penetrate the normall ...... tients with ulcerative colitis

@en

Bacteria penetrate the normall ...... ients with ulcerative colitis.

@nl

type

label

Bacteria penetrate the normall ...... tients with ulcerative colitis

@en

Bacteria penetrate the normall ...... ients with ulcerative colitis.

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prefLabel

Bacteria penetrate the normall ...... tients with ulcerative colitis

@en

Bacteria penetrate the normall ...... ients with ulcerative colitis.

@nl

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GUTJNL-2012-303207

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Bacteria penetrate the normall ...... tients with ulcerative colitis

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Andrew T Gewirtz

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Fayez K Ghishan

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Frederic A Carvalho

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Henrik Sjövall

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Hua Xu

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Jenny K Gustafsson

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Jessica Holmén-Larsson

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Lijun Xia

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P2860

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice

Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice

Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Unravelling the pathogenesis of inflammatory bowel disease

Interleukin-10-deficient mice develop chronic enterocolitis

Genetics and pathogenesis of inflammatory bowel disease

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

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281-291

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scholarly article

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10.1136/GUTJNL-2012-303207

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2

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63

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Gunnar C Hansson

Malin E. V. Johansson

Karolina S Jabbar

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2013-02-20T00:00:00Z

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235682474

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23426893

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3740207

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