Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.
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PKMζ knockdown disrupts post-ischemic long-term potentiation via inhibiting postsynaptic expression of aminomethyl phosphonic acid receptorsZinc wave during the treatment of hypoxia is required for initial reactive oxygen species activation in mitochondriaDifferential NMDA receptor-dependent calcium loading and mitochondrial dysfunction in CA1 vs. CA3 hippocampal neuronsSpreading depression and related events are significant sources of neuronal Zn2+ release and accumulation.Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia.Clioquinol inhibits zinc-triggered caspase activation in the hippocampal CA1 region of a global ischemic gerbil modelRAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environmentZn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity.Zinc bells rang in Jerusalem!Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes.Precise spatial and temporal control of oxygen within in vitro brain slices via microfluidic gas channels.Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory.Zinc: indications in brain disorders.TPEN, a Specific Zn2+ Chelator, Inhibits Sodium Dithionite and Glucose Deprivation (SDGD)-Induced Neuronal Death by Modulating Apoptosis, Glutamate Signaling, and Voltage-Gated K+ and Na+ Channels.TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemiaCytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium.Zn²+ chelation improves recovery by delaying spreading depression-like events.Disparate roles of zinc in chemical hypoxia-induced neuronal death.ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution.A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial functionMechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons.Redox regulation of intracellular zinc: molecular signaling in the life and death of neuronsThe neurophysiology and pathology of brain zinc.Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model.Zinc Modulates Nanosilver-Induced Toxicity in Primary Neuronal Cultures.Intracellular dialysis disrupts Zn2+ dynamics and enables selective detection of Zn2+ influx in brain slice preparations.Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currentsTopographical analysis of reactive zinc in the central nervous system of adult zebrafish (Danio rerio)Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.In vivo astrocytic Ca(2+) signaling in health and brain disorders.Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review)Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria.The interactive roles of zinc and calcium in mitochondrial dysfunction and neurodegeneration.The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.Zinc: new clues to diverse roles in brain ischemia.Ca permeable AMPA channels in diseases of the nervous system.Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases.Temporal fate specification and neural progenitor competence during development.The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.
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Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia.
@en
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia.
@nl
type
label
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia.
@en
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia.
@nl
prefLabel
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia.
@en
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia.
@nl
P2093
P2860
P921
P1476
Intracellular Zn2+ accumulatio ...... deprivation model of ischemia
@en
P2093
C William Shuttleworth
John H Weiss
Yuliya V Medvedeva
P2860
P304
P356
10.1523/JNEUROSCI.4604-08.2009
P407
P50
P577
2009-01-01T00:00:00Z