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Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migrationLarge-scale structural analysis of the classical human protein tyrosine phosphatomeDramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesisSalicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsFunctional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populationsSUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation.Identification of PTPsigma as an autophagic phosphatase.Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stabilityInhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA OncoproteinProtein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuriaSHP2 is induced by the HBx-NF-κB pathway and contributes to fibrosis during human early hepatocellular carcinoma development.Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis.Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancerSmall molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.SHP2E76K mutant promotes lung tumorigenesis in transgenic miceMultivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cellsAssociation of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitorsSHP-2 phosphatase activity is required for PECAM-1-dependent cell motility.Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenesSHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.Protein tyrosine phosphatases as potential therapeutic targets.Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population.Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.SHP2 is a target of the immunosuppressant tautomycetin.Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutationSHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.Critical role of Shp2 in tumor growth involving regulation of c-Myc
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
@en
The tyrosine phosphatase Shp2
@nl
type
label
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
@en
The tyrosine phosphatase Shp2
@nl
prefLabel
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
@en
The tyrosine phosphatase Shp2
@nl
P2860
P1476
The tyrosine phosphatase Shp2 (PTPN11) in cancer
@en
P2093
Demetrios Kalaitzidis
Gordon Chan
P2860
P2888
P304
P356
10.1007/S10555-008-9126-Y
P577
2008-06-01T00:00:00Z