Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice - Wikidata - awgldk - TriplyDB

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

http://www.wikidata.org/entity/Q37089101

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ELOVL5 mutations cause spinocerebellar ataxia 38 Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle Whole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcome The Genetic Architecture of Murine Glutathione Transferases ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38)Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis.Saturated fats: a perspective from lactation and milk composition Metabolism of very long-chain Fatty acids: genes and pathophysiology.Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation.Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice.Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance.Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk.The role of fatty acid elongation in epidermal structure and function.Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study.Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver Modulation of lipid metabolism in glycyrrhizic acid-treated rats fed on a high-calorie diet and exposed to short or long-term stress.Health implications of high dietary omega-6 polyunsaturated Fatty acids.The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid.Fatty acid regulation of hepatic lipid metabolism.The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells.The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities.Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.Omega-3 fatty acid supplementation and cardiovascular disease.Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.Genome-wide association studies for fatty acid metabolic traits in five divergent pig populations Eicosanoids in metabolic syndrome.Fatty acid metabolism: Implications for diet, genetic variation, and disease.Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat's liver

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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

http://www.wikidata.org/entity/Q37089101

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 October 2008

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

@en

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.

@nl

type

label

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

@en

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.

@nl

prefLabel

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

@en

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.

@nl

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JLR.M800383-JLR200

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Journal of Lipid Research

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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

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Jay D Horton

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Robert E Hammer

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Young-Ah Moon

http://www.w3.org/2001/XMLSchema#string

P2860

A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Identification and expression of mammalian long-chain PUFA elongation enzymes

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade

Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

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412-423

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scholarly article

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10.1194/JLR.M800383-JLR200

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3

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50

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2008-10-06T00:00:00Z

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18838740

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2638104

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