Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice
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Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damageSelective ROCK2 inhibition in focal cerebral ischemiaNovel Insights into the Roles of Rho Kinase in CancerThe Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular DiseaseObesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunitiesThe Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosisRho kinase proteins--pleiotropic modulators of cell survival and apoptosisPyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -IIFocal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protectionTGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunctionRho-associated kinase activity is a predictor of cardiovascular outcomes.Rho kinase: an important mediator of atherosclerosis and vascular disease.Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokersROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice.Estrogen receptor-beta prevents cardiac fibrosis.Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.Requirement of Rac1 in the development of cardiac hypertrophy.Rho-kinase in development and heart failure: insights from genetic modelsRhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosisRho kinase as a therapeutic target in cardiovascular disease.Role of Rho kinase isoforms in murine allergic airway responses.SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expressionAbrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency.ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in miceThe Role of the Rho/ROCK Pathway in Ang II and TGF-β1-Induced Atrial Remodeling.Rho-GTPase and Atherosclerosis: Pleiotropic Effects of StatinsRnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.Physiological role of ROCKs in the cardiovascular systemROCK1 mediates leukocyte recruitment and neointima formation following vascular injuryRnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis.ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progressionInhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
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Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 October 2005
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice
@en
Decreased perivascular fibrosi ...... CK1+/- haploinsufficient mice.
@nl
type
label
Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice
@en
Decreased perivascular fibrosi ...... CK1+/- haploinsufficient mice.
@nl
prefLabel
Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice
@en
Decreased perivascular fibrosi ...... CK1+/- haploinsufficient mice.
@nl
P2093
P2860
P1433
P1476
Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice
@en
P2093
Hyung-Hwan Kim
James K Liao
Kensuke Noma
Minoru Satoh
Naotsugu Oyama
Yoshiyuki Rikitake
P2860
P304
P356
10.1161/CIRCULATIONAHA.105.584623
P407
P577
2005-10-31T00:00:00Z