Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice - Wikidata - awgldk - TriplyDB

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

http://www.wikidata.org/entity/Q37092280

about

Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage Selective ROCK2 inhibition in focal cerebral ischemia Novel Insights into the Roles of Rho Kinase in Cancer The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis Rho kinase proteins--pleiotropic modulators of cell survival and apoptosis Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction Rho-associated kinase activity is a predictor of cardiovascular outcomes.Rho kinase: an important mediator of atherosclerosis and vascular disease.Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice.Estrogen receptor-beta prevents cardiac fibrosis.Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.Requirement of Rac1 in the development of cardiac hypertrophy.Rho-kinase in development and heart failure: insights from genetic models RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis Rho kinase as a therapeutic target in cardiovascular disease.Role of Rho kinase isoforms in murine allergic airway responses.SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency.ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice The Role of the Rho/ROCK Pathway in Ang II and TGF-β1-Induced Atrial Remodeling.Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.Physiological role of ROCKs in the cardiovascular system ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis.ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

P2860

Q24318504-30FC8D76-81B3-4F00-807C-4CEA205BB664 Q24614558-789254BC-F216-49E4-8180-2221515AA309 Q26771368-D9C6052E-CC4E-44CF-A158-A877D1C48A99 Q26774795-A6555103-B764-41B7-A4F2-884540856DA4 Q26825697-6A1F082F-D453-4F3E-8424-C0029164893F Q27005980-F4F8E68B-9EF2-4AE8-BCFB-03FDA8997ED4 Q27023537-CC85F4D8-5963-4AB7-99F6-70277F770AC4 Q27675669-D6398FB5-7154-46B8-BA83-3A48E4331D2A Q28565264-BBA70E50-A27B-42DA-ABCD-4789582FF5B4 Q28571389-17FC9DB3-A1B5-4075-92B7-14D7ED1EA901 Q30440157-022590BC-C57E-45A7-A0C0-087F4463B122 Q33877795-604EB794-E80B-4CD8-A11E-6847BB546D8B Q33911873-37208D0F-A030-4A0A-A2FA-329BFE5D332C Q33960580-60610CB3-2E2E-4F1A-A0BA-978692773EBB Q33968841-2DF15ED3-C8DC-4374-ABD6-155DDCA0EC7E Q34066752-8F4EA2BE-8D5E-4F34-91BC-4F9CCBDE9CF5 Q34072195-FE3E22A3-193C-46F6-83F0-FA369AE8662E Q34088790-D77F2C4D-3147-48DE-887C-5C1F943E7D7C Q34172718-1B195514-2206-49F2-A719-7B5060A4C043 Q34220113-9FABE911-5B66-4FA8-A9B1-4ECC5452847D Q34362144-6BD9F018-1BC5-4F83-8392-666FF58B7F7D Q34585302-2CF80FB7-6782-4734-8D65-56195D426372 Q34893701-D97C67F3-E163-4B53-9206-F9BB513F6694 Q34989031-AEAE4ECB-9D93-4952-9237-22A79482625D Q35080715-92493489-FB28-47B4-A336-8803A82FA351 Q35352722-1DFFA546-2403-4259-9F60-CF2F0ECFD15B Q35687203-B48A1B82-982F-4EDD-8E54-59D2F45ABF83 Q35741910-9D77CB6C-1700-44F4-B998-922A6BC6C67E Q35913023-0EDD3DF6-7CD1-4BEF-BCE7-9AE8D3E7883A Q36002513-04584DBA-4994-4C0D-AA96-05C45CACF14A Q36057251-EEC4376A-950E-4E48-AF9F-F27DFB2D4723 Q36122896-1E1190A0-0DBF-4D3D-8F32-123103090544 Q36128353-5D636678-8507-4EB3-9AB9-5D948AC0AB46 Q36168823-154E57A4-2A71-4FB5-91D5-E5513338D77D Q36179543-45235A60-A947-4C37-806A-0572565F6288 Q36392528-C7DBC6A0-C41E-47A8-AAE5-27C9B8F8FAA8 Q36540884-383D9EC2-6DD0-41BD-B82B-706D0D6C9577 Q36576625-3B0EE6A6-EF4A-4858-944C-40F267D48CF7 Q36634247-8F28E87D-6675-4ED7-8DE5-512217C3AA2F Q36638211-87CF77B1-C428-491B-9960-99FA50E76547

P2860

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

http://www.wikidata.org/entity/Q37092280

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 31 October 2005

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice

@en

Decreased perivascular fibrosi ...... CK1+/- haploinsufficient mice.

@nl

type

label

Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice

@en

Decreased perivascular fibrosi ...... CK1+/- haploinsufficient mice.

@nl

prefLabel

Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice

@en

Decreased perivascular fibrosi ...... CK1+/- haploinsufficient mice.

@nl

P1433

Q37092280-57C3845A-24AE-42B1-8E55-5DFC5DB8B6C9

P1476

Q37092280-3D96119A-4D92-4170-872A-0FAD8BE8AEA3

P2093

Q37092280-383A7BAC-596B-4773-833F-C232FA94069B

Q37092280-62CFD9EE-4571-4535-9511-D61878DA8776

Q37092280-6DF760C4-2D98-4F97-85EA-957E614C7026

Q37092280-8F2F29E6-754A-4FC7-B0BD-A3E0CEA119A0

Q37092280-9E99C0A1-5D38-4E47-A479-374D8A9A5A97

Q37092280-DA82CAEE-409D-4166-89F5-FD4BD6E1858D

P2860

Q37092280-0BAC727A-60AE-45C9-9DBA-B19AE3EB0C82

Q37092280-0D41F9AF-CB75-47F8-A69B-805B04451876

Q37092280-0E4A4043-0794-496F-ABA8-9A5CC82239C0

Q37092280-12C4B0BA-F9AF-4066-965E-A4015DA10550

Q37092280-16151506-54CE-4B5C-AE5D-570BB59D74EA

Q37092280-1ABC89B6-81D1-4530-8A66-5ED4FAEFCEC1

Q37092280-1EEC69AF-64B1-4727-BC29-B6716AFC5399

Q37092280-498AE157-A46C-4D38-826A-7ABD3DFED52D

Q37092280-500EAF16-6CC7-4FE8-ADD7-72DA36A0EE7B

Q37092280-6DED3362-ACA3-4F60-A766-695BE148704B

P304

Q37092280-852A01A5-38AC-4DF3-BCAA-8113A475F70F

P31

Q37092280-939CA52E-8103-43F0-861A-A9F0CCE1A0FD

P356

Q37092280-0D055CD3-EE8E-4219-B766-3125ABFB3A7F

P407

Q37092280-DB7CB3A5-C979-405C-B581-EA73F0B26A8E

P433

Q37092280-23DB7854-E47E-41FA-903B-B2AF16002730

P478

Q37092280-6661E40B-E775-4326-9228-512DBCEF3789

P50

Q37092280-DE2D9527-24D9-4B79-B6AE-F2F849C0E626

P577

Q37092280-2F5DA6AB-7896-4BDC-9420-9253D91EDF51

P698

Q37092280-2BF56585-49E1-4DA3-93E2-F4C6DC29A613

P921

Q37092280-72FD2589-AC24-4033-9A53-0AC3DC92ADBF

P932

Q37092280-A7CEFD84-8198-4A78-984F-309947D62EE7

P356

CIRCULATIONAHA.105.584623

P1433

P1476

Decreased perivascular fibrosi ...... OCK1+/- haploinsufficient mice

@en

P2093

Hyung-Hwan Kim

http://www.w3.org/2001/XMLSchema#string

James K Liao

http://www.w3.org/2001/XMLSchema#string

Kensuke Noma

http://www.w3.org/2001/XMLSchema#string

Minoru Satoh

http://www.w3.org/2001/XMLSchema#string

Naotsugu Oyama

http://www.w3.org/2001/XMLSchema#string

Yoshiyuki Rikitake

http://www.w3.org/2001/XMLSchema#string

P2860

Rocks: multifunctional kinases in cell behaviour

Protein kinase cascades in the regulation of cardiac hypertrophy

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

Arterial hypertension and cardiac arrhythmias.

Prognostic implications of left ventricular hypertrophy.

The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis.

The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis.

P304

2959-2965

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1161/CIRCULATIONAHA.105.584623

http://www.w3.org/2001/XMLSchema#string

P407

P433

19

http://www.w3.org/2001/XMLSchema#string

P478

112

http://www.w3.org/2001/XMLSchema#string

P50

P577

2005-10-31T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16260635

http://www.w3.org/2001/XMLSchema#string

P921

haploinsufficiency

P932

2640100

http://www.w3.org/2001/XMLSchema#string