Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
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Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 RetrotranspositionRetinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategiesStem cells in genetically-engineered mouse models of prostate cancerThe many ways to make a luminal cell and a prostate cancer cellRoles for Hedgehog signaling in adult organ homeostasis and repairBiologic and clinical significance of androgen receptor variants in castration resistant prostate cancerTranslating insights of AR signaling from mouse modelsQuantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cellsCell-of-Origin of Cancer versus Cancer Stem Cells: Assays and InterpretationsL1 retrotransposons, cancer stem cells and oncogenesisSonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiationMouse models of prostate cancer: picking the best model for the question.Copy number alteration burden predicts prostate cancer relapseSystematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer.The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice.Luminal cells are favored as the cell of origin for prostate cancerSPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.Single luminal epithelial progenitors can generate prostate organoids in culture.Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinomaMolecular pathways and targets in prostate cancerProstate epithelial stem and progenitor cells.Constitutive activity of the androgen receptor.Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2KIdentification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer.Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas.Hedgehog signaling in prostate epithelial-mesenchymal growth regulation.Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.Cell kinetic studies fail to identify sequentially proliferating progenitors as the major source of epithelial renewal in the adult murine prostate.Pten Regulates Epithelial Cytodifferentiation during Prostate Development.Isolated Rat Epididymal Basal Cells Share Common Properties with Adult Stem CellsProstate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment.Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.Stem cell plasticity. Plasticity of epithelial stem cells in tissue regenerationAndrogen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells.Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors.Targeting tumor metastases: Drug delivery mechanisms and technologies.Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia
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Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 24 February 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Lineage analysis of basal epit ...... prostate cancer heterogeneity
@en
Lineage analysis of basal epit ...... prostate cancer heterogeneity.
@nl
type
label
Lineage analysis of basal epit ...... prostate cancer heterogeneity
@en
Lineage analysis of basal epit ...... prostate cancer heterogeneity.
@nl
prefLabel
Lineage analysis of basal epit ...... prostate cancer heterogeneity
@en
Lineage analysis of basal epit ...... prostate cancer heterogeneity.
@nl
P2093
P2860
P356
P1433
P1476
Lineage analysis of basal epit ...... prostate cancer heterogeneity
@en
P2093
Andrea Califano
Antonina Mitrofanova
Cory Abate-Shen
Michael M Shen
Robert D Cardiff
Sarah K Bergren
Zhu A Wang
P2860
P2888
P304
P356
10.1038/NCB2697
P577
2013-02-24T00:00:00Z