Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K - Wikidata - awgldk - TriplyDB

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

http://www.wikidata.org/entity/Q34880928

about

Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy Stimuli-Responsive Mesoporous Silica NPs as Non-viral Dual siRNA/Chemotherapy Carriers for Triple Negative Breast Cancer.eEF2K--a new target in breast cancers with combined inactivation of p53 and PTEN Identification of cell proliferation, immune response and cell migration as critical pathways in a prognostic signature for HER2+:ERα- breast cancer.Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer.The origin of breast tumor heterogeneity.Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties.The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer.MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase.Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy.Triple negative breast cancer chemosensitivity and chemoresistance: current advances in biomarkers indentification.Effect of Helix aspersa extract on TNFα, NF-κB and some tumor suppressor genes in breast cancer cell line Hs578T.Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia.Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development.microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer.Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity.Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN-deficient prostate cancer Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation.Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer.Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis.Protein Kinase Targets in Breast Cancer.Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer.Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation.Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia.Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors.

P2860

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P2860

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

http://www.wikidata.org/entity/Q34880928

description

2014 nî lūn-bûn

@nan

2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

@wuu

name

Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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EMBO Molecular Medicine

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Combined deletion of Pten and ...... ancer with dependency on eEF2K

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P2093

David Uehling

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Dong-Yu Wang

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Eldad Zacksenhaus

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Jeff C Liu

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Rima Al-awar

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Sean E Egan

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Sharon Wang

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Tak W Mak

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Veronique Voisin

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

The epithelial-mesenchymal transition generates cells with properties of stem cells

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

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1542-1560

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scholarly article

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10.15252/EMMM.201404402

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12

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6

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Alessandro Datti

Ming-Sound Tsao

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2014-10-20T00:00:00Z

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267158751

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25330770

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4287974

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