Interleukin 2 plays a central role in Th2 differentiation. - Wikidata - awgldk - TriplyDB

Interleukin 2 plays a central role in Th2 differentiation.

Interleukin 2 plays a central role in Th2 differentiation.

http://www.wikidata.org/entity/Q37095134

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The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation Maintenance of Immune Homeostasis through ILC/T Cell Interactions STAT6-dependent and -independent mechanisms in Th2 polarization IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets The differential expression of IL-4 and IL-13 and its impact on type-2 immunity History of interleukin-4 An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses Differentiation of effector CD4 T cell populations (*)Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4+Foxp3+ Regulatory T-Cells Genetic control of the inflammatory T-cell response in regulatory T-cell deficient scurfy mice.IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection.New insights into the regulation of T cells by gamma(c) family cytokines Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization.An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation.The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.Dysregulated cytokine expression by CD4+ T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+) T lymphocyte cytokine production.A mechanism for the initiation of allergen-induced T helper type 2 responses Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.Complex interactions of transcription factors in mediating cytokine biology in T cells.Stat5a/b are essential for normal lymphoid development and differentiation.Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells.Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity.Dendritic cells and B cells: unexpected partners in Th2 development.Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo CD4 T cells: fates, functions, and faults Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.

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Interleukin 2 plays a central role in Th2 differentiation.

http://www.wikidata.org/entity/Q37095134

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 05 March 2004

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Interleukin 2 plays a central role in Th2 differentiation.

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Interleukin 2 plays a central role in Th2 differentiation.

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type

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Interleukin 2 plays a central role in Th2 differentiation.

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Interleukin 2 plays a central role in Th2 differentiation.

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prefLabel

Interleukin 2 plays a central role in Th2 differentiation.

@en

Interleukin 2 plays a central role in Th2 differentiation.

@nl

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PNAS.0400339101

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Proceedings of the National Academy of Sciences of the United States of America

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Interleukin 2 plays a central role in Th2 differentiation

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P2093

Howard A Young

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Jane Hu-Li

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Javier Cote-Sierra

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Liying Guo

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Lynda Chiodetti

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William E Paul

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P2860

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Helper T cell differentiation is controlled by the cell cycle

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.

In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production.

An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines.

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

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3880-3885

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scholarly article

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10.1073/PNAS.0400339101

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11

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101

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2004-03-05T00:00:00Z

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7743975

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15004274

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374338

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