Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.
about
Interleukin-2 receptor signaling: at the interface between tolerance and immunityOpposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5The quantal theory of how the immune system discriminates between "self and non-self"Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 DiabetesInducing and Administering Tregs to Treat Human DiseaseDisturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus ErythematosusLow-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunityIL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammationEarly signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsetsAlong the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to MammalsDefective T cell activation and autoimmune disorder in Stra13-deficient miceThe regulation of FasL expression during activation-induced cell death (AICD)CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionCombining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death.Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway.Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity.Malignant catarrhal fever of cattle is associated with low abundance of IL-2 transcript and a predominantly latent profile of ovine herpesvirus 2 gene expression.Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9.Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjectsThe Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia.Tumour necrosis factor and other cytokines in murine lupus.When immunization leads to autoimmunity: chronic inflammation as a result of thymic and mucosal dysregulation in IL-2 knock-out mice.DNA vaccination and the immune responsiveness of neonates.Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion.Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell deathHigher expression of Bax in regulatory T cells increases vascular inflammation.IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cellsCTLA4-Ig: a novel immunosuppressive agent.Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatmentNew insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppressionCompensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling.A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivoInterleukin 2 signaling is required for CD4(+) regulatory T cell function.The enemy within: keeping self-reactive T cells at bay in the periphery.Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition.On the role of sIL-2R measurements in rheumatoid arthritis and cancers.
P2860
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P2860
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@ast
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@en
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@nl
type
label
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@ast
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@en
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@nl
prefLabel
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@ast
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@en
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@nl
P2093
P356
P1476
Generalized autoimmune disease ...... proliferation of CD4+ T cells.
@en
P2093
P304
P356
10.1002/EJI.1830251111
P407
P577
1995-11-01T00:00:00Z