PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes.
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Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysisHuman Cytomegalovirus Latency: Approaching the Gordian Knot.Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitroHuman cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entryThe HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesisThe role of PI3K/Akt in human herpesvirus infection: From the bench to the bedsideBH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells.Human cytomegalovirus persistence.Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.Human cytomegalovirus induction of a unique signalsome during viral entry into monocytes mediates distinct functional changes: a strategy for viral disseminationHuman cytomegalovirus stimulates monocyte-to-macrophage differentiation via the temporal regulation of caspase 3.Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins.Viral binding-induced signaling drives a unique and extended intracellular trafficking pattern during infection of primary monocytes.Hippuristanol reduces the viability of primary effusion lymphoma cells both in vitro and in vivo.Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in ratsHCMV reprogramming of infected monocyte survival and differentiation: a Goldilocks phenomenon.Functional genomics approaches to understand cytomegalovirus replication, latency and pathogenesis.Human cytomegalovirus manipulation of latently infected cells.Treatment of cytomegalovirus infections beyond acute disease to improve human health.HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors.Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells.The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis.Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1.PI3K inhibition potentiates Bcl-2-dependent apoptosis in renal carcinoma cells.Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes.Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.Human cytomegalovirus inhibits apoptosis involving upregulation of the antiapoptotic protein Bag-1.Latency-associated viral interleukin-10 (IL-10) encoded by human cytomegalovirus modulates cellular IL-10 and CCL8 Secretion during latent infection through changes in the cellular microRNA hsa-miR-92a.HCMV utilizes a non-traditional STAT1 activation cascade via signaling through EGFR and integrins to efficiently promote the motility, differentiation, and polarization of infected monocytes.Human Cytomegalovirus Delays Neutrophil Apoptosis and Stimulates the Release of a Prosurvival Secretome.Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling.Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-specific Protease 24 and Regulating Iron Metabolism.Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection?Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from LatencyMonocytes and Macrophages as Viral Targets and Reservoirs
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PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 February 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@en
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@nl
type
label
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@en
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@nl
prefLabel
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@en
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@nl
P2093
P2860
P356
P1476
PI3K-dependent upregulation of ...... osis in short-lived monocytes.
@en
P2093
Alexander Parmater
Andrew D Yurochko
Gretchen L Bentz
M Shane Smith
Maciej T Nogalski
P2860
P304
P356
10.4049/JIMMUNOL.0903025
P407
P577
2010-02-19T00:00:00Z