Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
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Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinantSynergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell linesApproaches to Validate and Manipulate RNA Targets with Small Molecules in CellsSynthetic oligonucleotides: the development of antisense therapeutics.Antisense approaches for the treatment of cancer.The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexesDefining the factors that contribute to on-target specificity of antisense oligonucleotides.Advances in the development of therapeutic nucleic acids against cervical cancer.Anatomy of a joint venture: Dana Farber/Partners Cancer Care.A cytosine analog that confers enhanced potency to antisense oligonucleotides.Raf kinases: oncogenesis and drug discovery.Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancerDownstream intracellular effectors of epidermal growth factor receptor as targets for anticancer therapy.Selective Raf inhibition in cancer therapy.Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteinsAntisense oligonucleotide sequences targeting the muscarinic type 2 acetylcholine receptor enhance performance in the Morris water maze.TP53INP1 as new therapeutic target in castration-resistant prostate cancer.-CH2- lengthening of the internucleotide linkage in the ApA dimer can improve its conformational compatibility with its natural polynucleotide counterpart.Comparison of strategies targeting Raf-1 mRNA in ovarian cancer.Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo.Homologous human and murine antisense oligonucleotides targeting stat6. Functional effects on germline cepsilon transcript.Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway.C-Raf controlled pathways in the protection of tumor cells from apoptosis.Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis.Advances in therapeutic bacterial antisense biotechnology.The RAF family: an expanding network of post-translational controls and protein-protein interactions.
P2860
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P2860
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Sequence-specific antitumor ac ...... se mechanism of action in vivo
@en
Sequence-specific antitumor ac ...... e mechanism of action in vivo.
@nl
type
label
Sequence-specific antitumor ac ...... se mechanism of action in vivo
@en
Sequence-specific antitumor ac ...... e mechanism of action in vivo.
@nl
prefLabel
Sequence-specific antitumor ac ...... se mechanism of action in vivo
@en
Sequence-specific antitumor ac ...... e mechanism of action in vivo.
@nl
P2093
P2860
P356
P1476
Sequence-specific antitumor ac ...... se mechanism of action in vivo
@en
P2093
Altmann KH
Johnston JF
P2860
P304
15481-15484
P356
10.1073/PNAS.93.26.15481
P407
P577
1996-12-01T00:00:00Z