Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides
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The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivoStructural Basis of the RNase H1 Activity on Stereo Regular Borano Phosphonate DNA/RNA HybridsAntisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivoCharacterization of alpha-soluble N-ethylmaleimide-sensitive fusion attachment protein in alveolar type II cells: implications in lung surfactant secretion.Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.Synthetic oligonucleotides: the development of antisense therapeutics.The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells.Antisense approaches for the treatment of cancer.Comparison and evaluation of gene therapy and epigenetic approaches for wound healing.Potential therapeutic application of antisense oligonucleotides in the treatment of ocular diseases.Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes.Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.Antisense therapy for cancer.Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotidesPhosphorothioate antisense oligonucleotides induce the formation of nuclear bodiesSequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivoRole of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice.In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia.In vivo suppression of the renal Na+/Pi cotransporter by antisense oligonucleotides.Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides.5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy.Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain.In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase.Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modificationsPhosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus.Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells.Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model.Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C.Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice.Inhibition of atrial natriuretic peptide (ANP) C receptor expression by antisense oligodeoxynucleotides in A10 vascular smooth-muscle cells is associated with attenuation of ANP-C-receptor-mediated inhibition of adenylyl cyclase.Antisense oligonucleotides to the epidermal growth factor receptor.SupraMolecular BioVectors (SMBV) improve antisense inhibition of erbB-2 expression.Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals.In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model.Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes.Lipoplex size determines lipofection efficiency with or without serum.Basic calcium phosphate crystals activate p44/42 MAPK signal transduction pathway via protein kinase Cmicro in human fibroblasts.Cytosolic delivery of antisense oligonucleotides by listeriolysin O-containing liposomes.10th International Conference on gene therapy of cancer: 13 - 15 December 2001, San Diego, CA, USA.
P2860
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P2860
Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@ast
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@en
type
label
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@ast
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@en
prefLabel
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@ast
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@en
P2860
P356
P1476
Inhibition of protein kinase C ...... ntisense oligodeoxynucleotides
@en
P2860
P304
11762-11766
P356
10.1073/PNAS.91.24.11762
P407
P577
1994-11-01T00:00:00Z