Evolutionary divergence of the necroptosis effector MLKL. - Wikidata - awgldk - TriplyDB

Evolutionary divergence of the necroptosis effector MLKL.

Evolutionary divergence of the necroptosis effector MLKL.

http://www.wikidata.org/entity/Q37098819

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HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis Insane in the membrane: a structural perspective of MLKL function in necroptosis.EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.How do we fit ferroptosis in the family of regulated cell death?The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis.MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.Exploiting Cell Death Pathways for Inducible Cell Elimination to Modulate Graft-versus-Host-Disease.Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis Necroptosis: MLKL Polymerization Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

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Evolutionary divergence of the necroptosis effector MLKL.

http://www.wikidata.org/entity/Q37098819

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 February 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Evolutionary divergence of the necroptosis effector MLKL.

@en

Evolutionary divergence of the necroptosis effector MLKL.

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type

label

Evolutionary divergence of the necroptosis effector MLKL.

@en

Evolutionary divergence of the necroptosis effector MLKL.

@nl

prefLabel

Evolutionary divergence of the necroptosis effector MLKL.

@en

Evolutionary divergence of the necroptosis effector MLKL.

@nl

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Cell Death & Differentiation

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Evolutionary divergence of the necroptosis effector MLKL

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A L Mildenhall

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A Tripaydonis

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A Wardak

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I Matti

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J E Vince

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J M Hildebrand

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M C Tanzer

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P E Czabotar

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S N Young

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P2860

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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1185-1197

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scholarly article

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10.1038/CDD.2015.169

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7

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23

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2016-02-12T00:00:00Z

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26868910

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