MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. - Wikidata - awgldk - TriplyDB

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

http://www.wikidata.org/entity/Q37100064

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Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders Heterogeneity of white adipose tissue: molecular basis and clinical implications The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Metabolically healthy and unhealthy obese--the 2013 Stock Conference report The adipokine/ceramide axis: key aspects of insulin sensitization Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome The cell biology of fat expansion 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis MitoNEET Protects HL-1 Cardiomyocytes from Oxidative Stress Mediated Apoptosis in an In Vitro Model of Hypoxia and Reoxygenation PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.Conserved hydrogen bonding networks of MitoNEET tune Fe-S cluster binding and structural stability.Mitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol.The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis Minireview: Challenges and opportunities in development of PPAR agonists Influence of the definition of "metabolically healthy obesity" on the progression of coronary artery calcification.Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure.A novel and robust method for testing bimodality and characterizing porcine adipocytes of adipose tissue of 5 purebred lines of pig.Tracking adipogenesis during white adipose tissue development, expansion and regeneration.MitoNEET-mediated effects on browning of white adipose tissue.Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.Adipsin is an adipokine that improves β cell function in diabetes.The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1 PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding Obesity and cancer--mechanisms underlying tumour progression and recurrence Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration Fetal development of subcutaneous white adipose tissue is dependent on Zfp423.MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.Childhood obesity: immune response and nutritional approaches.The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.

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MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

http://www.wikidata.org/entity/Q37100064

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bilimsel makale

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scientific article published on 09 September 2012

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vedecký článok

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vetenskaplig artikel

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MitoNEET-driven alterations in ...... nsulin sensitivity in obesity.

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MitoNEET-driven alterations in ...... nsulin sensitivity in obesity.

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MitoNEET-driven alterations in ...... nsulin sensitivity in obesity.

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MitoNEET-driven alterations in ...... nsulin sensitivity in obesity.

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Nature Medicine

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MitoNEET-driven alterations in ...... insulin sensitivity in obesity

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Cai Li

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Christine M Kusminski

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G Roger Askew

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Jiyoung Park

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Philipp E Scherer

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Stephen B Spurgin

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William L Holland

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Ying Lin

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P2860

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins

Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor

Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe

High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity

A novel serum protein similar to C1q, produced exclusively in adipocytes

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1539-1549

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10.1038/NM.2899

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22961109

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